Evidence map›Paper›PMID 30226130›Full record

ArticleThe American journal of tropical medicine and hygiene2018

Highly Accurate Chimeric Proteins for the Serological Diagnosis of Chronic Chagas Disease: A Latent Class Analysis.

Fred Luciano Neves Santos, Ana Clara Paixão Campos, Leila Denise Alves Ferreira Amorim, Edimilson Domingos Silva, Nilson Ivo Tonin Zanchin, Paola Alejandra Fiorani Celedon, Rodrigo Pimenta Del-Rei, Marco Aurélio Krieger, Yara Miranda Gomes

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Double-antigen sandwich ELISA based on chimeric antigens for detection of antibodies to Trypanosoma cruzi in human sera - A phase II study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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  14. Frontiers in microbiology · 2024
    Article
  15. Assessment of Cross-Reactivity of ChimericDiagnostics (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Article
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  20. Chagas Immunochromatographic Rapid Test in the Serological Diagnosis ofFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fred Luciano Neves SantosGonçalo Moniz Institute, Oswaldo Cruz Foundation-Bahia, Salvador, Brazil.
Ana Clara Paixão CamposDepartment of Statistics, Institute of Mathematics and Statistics, Federal University of Bahia, Salvador, Brazil.
Leila Denise Alves Ferreira AmorimDepartment of Statistics, Institute of Mathematics and Statistics, Federal University of Bahia, Salvador, Brazil.
Edimilson Domingos SilvaInstitute of Technology in Immunobiologicals, Bio-Manguinhos, Oswaldo Cruz Foundation-Rio de Janeiro, Rio de Janeiro, Brazil.
Nilson Ivo Tonin ZanchinCarlos Chagas Institute, Oswaldo Cruz Foundation-Paraná, Curitiba, Brazil.
Paola Alejandra Fiorani CeledonMolecular Biology Institute of Paraná (IBMP), Curitiba, Brazil.
Rodrigo Pimenta Del-ReiGonçalo Moniz Institute, Oswaldo Cruz Foundation-Bahia, Salvador, Brazil.
Marco Aurélio KriegerMolecular Biology Institute of Paraná (IBMP), Curitiba, Brazil.
Yara Miranda GomesAggeu Magalhães Institute, Oswaldo Cruz Foundation-Pernambuco, Recife, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The existence of an imperfect reference standard presents complications when evaluating the unbiased performance of novel diagnostic techniques. This is especially true in the absence of a gold standard, as is the case in chronic Chagas disease (CD) diagnosis. To circumvent this constraint, we elected to use latent class analysis (LCA). Previously, our group demonstrated the high performance of four

Indexed as

Latent Class AnalysisAntigens, ProtozoanChagas DiseaseHumansImmunoassayProtozoan ProteinsReproducibility of ResultsSensitivity and SpecificitySerologic TestsTrypanosoma cruziAntigens, ProtozoanProtozoan Proteins

Identifiers

PMID30226130
PMCPMC6221211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.