ArticleInfection control and hospital epidemiology2018
Epidemiology and risk factors for recurrent Staphylococcus aureus colonization following active surveillance and decolonization in the NICU.
Article in Infection control and hospital epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Combatting a Tobramycin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit: the impact of hygiene intervention and antibiotic substitution.BMC infectious diseases · 2026Article
- Impact of methicillin-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit.Open forum infectious diseases · 2024Article
- Microbiome dysbiosis: a modifiable state and target to prevent Staphylococcus aureus infections and other diseases in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- A tale of two intensive care units (ICUs): BaselineInfection control and hospital epidemiology · 2023Article
- Reducing Staphylococcus aureus infections in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Management and Prevention of Staphylococcus aureus Infections in Children.Infectious disease clinics of North America · 2022Review
- Influence of the Incubator as Direct Patient Environment on Bacterial Colonization of Neonates.Microorganisms · 2021Article
- The effect of routine surveillance and decolonization on the rate of Staphylococcus aureus infections in a level IV neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Preterm infants at low risk for early-onset sepsis differ in early fecal microbiome assembly.Gut microbesArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo examine neonatal risk factors associated with recurrent Staphylococcus aureus colonization and to determine the genetic relatedness of S. aureus strains cultured from neonates before and after decolonization.Study designSingle-center retrospective cohort study of neonates admitted to the neonatal intensive care unit (NICU) from April 2013 to December 2015, during which weekly nasal cultures from hospitalized NICU patients were routinely obtained for S. aureus surveillance.
settingJohns Hopkins Hospital's 45-bed level IV NICU in Baltimore, Maryland.
methodsDemographics and clinical data were collected on all neonates admitted to the NICU with S. aureus nasal colonization who underwent mupirocin-based decolonization during the study period. A decolonized neonate was defined as a neonate with ≥1 negative culture after intranasal mupirocin treatment. Pulsed-field gel electrophoresis was used for strain typing.
resultsOf 2,060 infants screened for S. aureus, 271 (13%) were colonized, and 203 of these 271 (75%) received intranasal mupirocin. Of those treated, 162 (80%) had follow-up surveillance cultures, and 63 of these 162 infants (39%) developed recurrent colonization after treatment. The S. aureus strains were often genetically similar before and after decolonization. The presence of an endotracheal tube or nasal cannula/mask was associated with an increased risk of recurrent S. aureus colonization (hazard ratio [HR], 2.65; 95% confidence interval [CI], 1.19-5.90; and HR, 2.21; 95% CI, 1.02-4.75, respectively).
conclusionStrains identified before and after decolonization were often genetically similar, and the presence of invasive respiratory devices increased the risk of recurrent S. aureus nasal colonization in neonates. To improve decolonization efficacy, alternative strategies may be needed.
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