ArticleJournal of psychopharmacology (Oxford, England)2019
No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers.
Article in Journal of psychopharmacology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAnimal literature suggests an interaction between acetylcholine and serotonin on cognitive functions.
aimsThe aim of the current study was to assess whether both neurotransmitters interact during memory and novelty processing in humans.
methodsWe tested the interaction between acetylcholine and serotonin on cognitive functions in healthy volunteers by means of treatment with rivastigmine and citalopram, respectively.
resultsThe main result of the study showed that during the verbal learning task participants significantly recalled fewer words after citalopram treatment than after rivastigmine or placebo during both the immediate and delayed recall tasks. Rivastigmine was not able to reverse the impairing effect of citalopram.
conclusionsThis finding is in line with previous studies in which we manipulated acetylcholine and serotonin in different manners. Taken together, these studies in humans do not support the notion from animal studies that these two neurotransmitters interact on cognitive functions.
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