ArticleObesity (Silver Spring, Md.)2018
Associations of Maternal Diabetes During Pregnancy with Overweight in Offspring: Results from the Prospective TEDDY Study.
Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- How Do the Different Types of Maternal Diabetes during Pregnancy Influence Offspring Outcomes?Nutrients · 2022Pooled it
- Maternal pre-pregnancy BMI and early childhood adiposity trajectories: longitudinal evidence from the Taiwan birth cohort study.BMC public health · 2026Article
- GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study.Diabetes care · 2025Article
- Anthropometric growth trajectories of children presenting with presumptive pulmonary TB.IJTLD open · 2025Article
- Review
- Article
- Maternal glucose homeostasis during pregnancy in women with overweight or obesity and offspring metabolic health.Scientific reports · 2024Article
- Maternal gestational diabetes and childhood adiposity risk from 6 to 8 years of age.International journal of obesity (2005) · 2024Article
- The risk prediction of intergenerational transmission of overweight and obesity between mothers and infants during pregnancy.BMC pregnancy and childbirth · 2024Article
- Hyperglycemia in Pregnancy and Women's Health in the 21st Century.International journal of environmental research and public health · 2022Review
- Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating Autophagy.Metabolites · 2022Article
- Histomorphometric and oxidative evaluation of the offspring's testis from type 2 diabetic female rats treated with metformin and pentoxifylline.International journal of experimental pathology · 2022Review
- GAD65 autoantibodies and glucose tolerance in offspring born to women with and without type 1 diabetes (The EPICOM study).Endocrinology, diabetes & metabolism · 2022Article
- Prevalence and reasons of increased type 2 diabetes in Gulf Cooperation Council Countries.Saudi medical journal · 2021Review
- Type 2 Diabetes in Youth: the Role of Early Life Exposures.Current diabetes reports · 2020Review
- Persistent effects of in utero overnutrition on offspring adiposity: the Exploring Perinatal Outcomes among Children (EPOCH) study.Diabetologia · 2019Article
- Developmental overnutrition and obesity and type 2 diabetes in offspring.Diabetologia · 2019Review
- Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction.Journal of the Endocrine Society · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
objectiveThis study aimed to determine the relationship between different forms of, and potential pathways between, maternal diabetes and childhood obesity at different ages.
methodsProspective cohort data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which was composed of 5,324 children examined from 0.25 to 6 years of age, were analyzed. Cross-sectional and longitudinal analyses taking into account potential confounders and effect modifiers such as maternal prepregnancy BMI and birth weight z scores were performed.
resultsOffspring of mothers with gestational diabetes mellitus (GDM) or type 1 diabetes mellitus (T1DM) showed a higher BMI standard deviation score and increased risk for overweight and obesity at 5.5 years of age than offspring of mothers without diabetes. While these associations could be substantially explained by maternal prepregnancy BMI in offspring of mothers with GDM, significant associations disappeared after adjustment for birth weight z scores in offspring of T1DM mothers. Furthermore, overweight risk became stronger with increasing age in offspring of mothers with diabetes compared with offspring of mothers without diabetes.
conclusionsMaternal diabetes is associated with increased risk of offspring overweight, and the association appears to get stronger as children grow older. Indeed, intrauterine exposure to maternal T1DM may predispose children to later obesity through increased birth weight, while maternal BMI is more important in children exposed to GDM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.