Observational studyClinical cardiology2018
Sex-related differences in left ventricular diastolic function and arterial elastance during admission in patients with heart failure with preserved ejection fraction: The PURSUIT HFpEF study.
Observational study in Clinical cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Alterations in left atrial volume and function after atrial fibrillation ablation evaluated by three-dimensional speckle-tracking echocardiography.Scientific reports · 2026Article
- Strain-based characterization of atrioventricular and left atrial remodelling in rat models of heart failure with preserved ejection fraction.Experimental physiology · 2026Article
- The diagnosis and subclassification of heart failure with preserved ejection fraction: a review.Heart failure reviews · 2026Review
- Association of Cardiovascular Health and Genetic Risk for Left Ventricular Mass with Left Ventricular Structure, Function, and Incident Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology - National Heart Failure Registry, India.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Sex Differences in Diastolic Function Following Myocardial Infarction on Doppler Echocardiography.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Due Diligence of a Diastolic Index as a Prognostic Factor in Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2023Article
- Pericardial effusion following percutaneous left atrial appendage closure using the LAmbre device.Frontiers in cardiovascular medicine · 2023Article
- Impact of Sex in Left Atrial Indices for Prognosis of Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2022Article
- Observational
- Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models.JACC. Basic to translational science · 2022Review
- Sex differences in acute cardiovascular care: a review and needs assessment.Cardiovascular research · 2022Review
- Observational
- Prognostic significance of the HFA-PEFF score in patients with heart failure with preserved ejection fraction.ESC heart failure · 2021Observational
- Sex Differences in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2021Observational
- Diastolic index as a short-term prognostic factor in heart failure with preserved ejection fraction.Open heart · 2020Observational
- Factors Associated With Elevated N-Terminal Pro B-Type Natriuretic Peptide Concentrations at the Convalescent Stage and 1-Year Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.Circulation reports · 2020Article
- Considerable scatter in the relationship between left atrial volume and pressure in heart failure with preserved left ventricular ejection fraction.Scientific reports · 2020Article
- Protracted impairment of left atrial compliance after cryoballoon ablation in recurrence-free patients with paroxysmal atrial fibrillation.American journal of cardiovascular disease · 2020Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously reported that an index of afterload-related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e'/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. We aimed to determine sex-related differences in the E/e'-related indices for left ventricular diastolic function and their related factors during admission in patients with heart failure with preserved ejection fraction (HFpEF). HYPOTHESIS: Elderly HFpEF women exhibit severe left ventricular diastolic dysfunction associated with different left atrioventricular volume ratio.
methodsWe divided 267 patients with HFpEF (men/women, 116/151) into two groups by age (≥75 years, n = 212; <75 years, n = 55). We examined the alterations of E/e', E/e'/stroke volume index = Ed, and Ed/Ea, and cardiac structure during admission.
resultsEd and Ea were significantly higher in women than in men, at admission, especially in patients ≥75 years. Before discharge, not only Ed and Ea but also Ed/Ea was significantly higher in women than in men, especially in patients ≥75 years. Elderly female patients had larger left atrial than left ventricular volume.
conclusionsHigher afterload-related left ventricular diastolic elastance, Ed/Ea, in association with higher arterial elastance, Ea, accompanied by left atrioventricular volume mismatch was observed in elderly HFpEF women.
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