Evidence map›Paper›PMID 30225760›Full record

ArticleMolecular imaging and biology2019

Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.

Ilwoo Park, Janine M Lupo, Sarah J Nelson

Abstract read
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Kinetic analysis of multi-resolution hyperpolarizedMagnetic resonance in medicine · 2022
    Article
  6. Article
  7. Article
  8. HyperpolarizedNMR in biomedicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ilwoo ParkDepartment of Radiology, Chonnam National University Medical School, Jeabongro 42, Donggu, Gwangju, 61469, South Korea. ipark@jnu.ac.kr.ORCID 0000-0001-6022-8363
Janine M LupoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Sarah J NelsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Funding

Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
RESPONSE TO THERAPY FOR PATIENTS WITH GLIOMA USING HYPERPOLARIZED C-13 PYRUVATER21CA170148 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, SARAH J. · 2012 to 2013
$631k
NCI NIH HHS P01 CA118816NCI NIH HHS R21 CA170148NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

purposeThe purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1- PROCEDURES: C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-

resultsNormalized peak height from DSC imaging showed substantial correlations with normalized lactate (r = 0.6, p = 0.02) and total carbon (r = 0.6, p = 0.02) from hyperpolarized C-13 MRSI data.

conclusionsSince the peak height in the ΔR2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.

Indexed as

Magnetic Resonance ImagingPerfusionAnimalsBrainBrain NeoplasmsCarbon IsotopesCell Line, TumorContrast MediaDisease Models, AnimalGadoliniumGlioblastomaHumansPyruvic AcidRats, NudeXenograft Model Antitumor AssaysCarbon-13Carbon IsotopesContrast MediaGadoliniumPyruvic AcidBrain tumorDynamic nuclear polarizationDynamic susceptibility contrast imagingGlioblastomaHyperpolarized carbon-13Magnetic resonance spectroscopic imagingPerfusionPyruvate

Identifiers

PMID30225760
PMCPMC8172073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.