ArticleMikrochimica acta2018
Single cell immunodetection of Escherichia coli O157:H7 on an indium-tin-oxide electrode by using an electrochemical label with an organic-inorganic nanostructure.
Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 20 citations in OpenAlex.
- Design of skin-permeable organic-inorganic hybrid nanoparticles.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Review
- Recent Progress on the Electrochemical Biosensing ofBiosensors · 2020Review
- Recent progress in nanomaterial-based electrochemical biosensors for pathogenic bacteria.Mikrochimica acta · 2019Review
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A rapid and highly sensitive method is described for the detection of enterohemorrhagic Escherichia coli O157:H7. An organic-inorganic nanostructure in which numerous gold nanoparticles (AuNPs) are enclosed with polyaniline (PANI) was utilized as an electrochemical label. The nanostructure showed (a) strong light scattering intensity due to the coupling effect of the surface plasmon resonance based on the presence of AuNPs, and (b) high electrochemical response due to the redox activity of PANI. To achieve selectivity, antibody against E. coli O157:H7 was immobilized on the surface of the nanostructure. The method exploits the combination of strong adsorption of bacterial cells onto the indium-tin-oxide (ITO) glass electrode without any special processing and specific binding of the nanostructured label to E. coli O157:H7. This enables the electrochemical detection of a single cell on the ITO electrode. The electrochemical response to E. coli O157:H7 was 30-fold higher than that to other types of bacteria. This procedure can be applied to the determination of E. coli O157:H7 even in the presence of other bacteria. Graphical abstract Schematic of a voltammetric immunoassay for Escherichia coli O157:H7 by using a nanocomposite consisting of gold nanoparticles and polyaniline on an ITO electrode.
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