Evidence map›Paper›PMID 30225645›Full record

ReviewPediatric radiology2019

Imaging findings of sterile pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome: differential diagnosis and review of the literature.

Claudia Martinez-Rios, Mehul P Jariwala, Kerri Highmore, Karen Watanabe Duffy, Lynn Spiegel, Ronald M Laxer, Jennifer Stimec

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Pediatric Systemic Autoinflammatory Disorders: An Overview.Current allergy and asthma reports · 2025
    Review
  3. Chronic Noninfectious Osteomyelitis: A Review of Imaging Findings.The Indian journal of radiology & imaging · 2025
    Article
  4. Article
  5. [Analysis of clinical features and treatment of pyoderma gangrenosum].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022
    Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Periodic fever syndromes and the autoinflammatory diseases (AIDs).Journal of translational autoimmunity · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Claudia Martinez-RiosPediatric Radiology Division, Department of Medical Imaging, University of Ottawa, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada. claudiamonica@gmail.com.ORCID http://orcid.org/0000-0001-8591-9822
Mehul P JariwalaDivision of Pediatric Rheumatology, Department of Pediatrics, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada.
Kerri HighmorePediatric Radiology Division, Department of Medical Imaging, University of Ottawa, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
Karen Watanabe DuffyDivision of Rheumatology, Department of Pediatrics, University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Lynn SpiegelDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Ronald M LaxerDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Jennifer StimecDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
University of Ottawa · CAUniversity of Toronto · CARoyal University Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result of a mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene located on chromosome 15, which results in an abnormal overproduction of the pro-inflammatory cytokine interleukin-1β (IL-1). This syndrome clinically manifests as early onset of recurrent episodes of acute aseptic inflammation of the joints, generally occurring in the first two decades of life, followed by manifestation of characteristic skin lesions in the third decade, after an obvious decline in the joint symptoms. Although uncommon, the potential clinical implications of PAPA syndrome warrant an appropriate diagnosis in a timely fashion.

Indexed as

Acne VulgarisAdolescentArthritis, InfectiousDiagnosis, DifferentialHumansMalePyoderma GangrenosumSyndromeAcneArthritisChildrenGenetic mutationMagnetic resonance imagingMusculoskeletalPyoderma gangrenosumPyogenic arthritis, pyogrenosum and acne syndrome

Identifiers

PMID30225645
OpenAlexW2891535849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.