ArticleBreast cancer research and treatment2018
Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimal Imaging Methods to Reduce Repeat Surgery in Invasive Breast Cancer
Intraoperative Detection of Breast Cancer by Electrosurgical Gas Analysis and Artificial Intelligence
Who cites it
20 citing papers in PubMed.
- Can micro-CT distinguish between solid lung tumors? A comparative evaluation including solid adenocarcinoma, non-keratinizing squamous cell carcinoma, and carcinoid tumor.Journal of pathology and translational medicine · 2026Article
- Rapid Arbitrary-Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Feasibility of computed tomography-derived surgical margin assessment in an ex vivo sublobar lung resection model.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Incidence and severity of acute radiation induced toxicities among breast cancer patients treated with adjuvant radiotherapy at a major cancer treatment center in Ghana.Translational oncology · 2024Article
- Engineering the future of 3D pathology.The journal of pathology. Clinical research · 2024Article
- The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective.Diagnostics (Basel, Switzerland) · 2023Review
- Breast-Conserving Surgery Margin Guidance Using Micro-Computed Tomography: Challenges When Imaging Radiodense Resection Specimens.Annals of surgical oncology · 2023Article
- Ultra-Fast Portable and Wearable Sensing Design for Continuous and Wide-Spectrum Molecular Analysis and Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Emerging and future use of intra-surgical volumetric X-ray imaging and adjuvant tools for decision support in breast-conserving surgery.Current opinion in biomedical engineering · 2022Article
- Article
- Intraoperative imaging in pathology-assisted surgery.Nature biomedical engineering · 2022Review
- Usefulness of microfocus computed tomography in life science research: preliminary study using murine micro-hepatic tumor models.Surgery today · 2022Article
- Development of intraoperative assessment of margins in breast conserving surgery: a narrative review.Gland surgery · 2022Review
- Developing diagnostic assessment of breast lumpectomy tissues using radiomic and optical signatures.Scientific reports · 2021Article
- Optical scatter imaging of resected breast tumor structures matches the patterns of micro-computed tomography.Physics in medicine and biology · 2021Article
- Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography.Scientific reports · 2021Article
- Article
- Structured light imaging for breast-conserving surgery, part I: optical scatter and color analysis.Journal of biomedical optics · 2019Article
- Biomedical Imaging: Principles, Technologies, Clinical Aspects, Contrast Agents, Limitations and Future Trends in Nanomedicines.Pharmaceutical research · 2019Review
- Review of methods for intraoperative margin detection for breast conserving surgery.Journal of biomedical optics · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRoughly 23% of breast conserving surgery (BCS) patients undergo a second re-excision procedure due to pathologically positive surgical margins. We investigated the feasibility and potential value of micro-Computed Tomography (micro-CT) as a surgical margin guidance tool during BCS.
methodsA cohort of 32 BCS specimens was prospectively imaged with a pre-clinical micro-CT system upon arrival in the surgical pathology laboratory. Reconstructed micro-CT scans were evaluated retrospectively by an experienced breast radiologist, who provided binary determinations whether lesions extended to the specimen margin. These readings were then compared to the final pathological diagnosis and to 2D specimen radiography readings.
resultsOf the 32 specimens imaged, 28 had malignant and four had benign pathological diagnoses. Overall five (four malignant, one benign) of the 32 specimens had lesion tissue extending to the margin. For all 32 specimens, micro-CT reconstructions were calculated (< 4 min. acquisition + reconstruction time) and each specimen was volumetrically analyzed by a radiologist. Of the 28 malignant specimen readings, 18 matched the final pathological diagnosis [64%, 95 CI (47%-81%)], with a negative predictive value of 89% [95 CI (74%-96%)]. Micro-CT readings revealed changes in the tumor location and margin status as compared to single-projection radiography readings.
conclusionsMicro-CT scanning of BCS specimens enabled margin status assessment over the entirety of the surgical surface in a clinically relevant time frame, provided additional spatial information over single-projection radiography, and may be a potentially useful BCS guidance tool.
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Registered trials
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