ArticleBreast cancer research and treatment2018
Young age at diagnosis is associated with worse prognosis in the Luminal A breast cancer subtype: a retrospective institutional cohort study.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- Folate intake and the risk of breast cancer: an up-to-date meta-analysis of prospective studies.European journal of clinical nutrition · 2019Pooled it
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- Tumor genomics in patients younger than 40 years of age with metastatic breast cancer.NPJ precision oncology · 2026Article
- Age-stratified analysis of invasive lobular carcinoma reveals comparable clinicopathological and molecular features across age groups.Discover oncology · 2026Article
- Article
- Frequency of somatic and germline variants of predisposition genes in young Chinese women with breast cancer.Breast cancer research and treatment · 2025Article
- Subtype-Specific Survival of Young Women with Breast Cancer and Its Interaction with the Germline BRCA Status.Cancers · 2024Article
- Prevalence of targetable genomic alterations in young women with advanced breast cancer: a cross-sectional study.Breast cancer research and treatment · 2024Article
- An audit of breast cancer in patients 40 years and younger in two Johannesburg academic hospitals.SA journal of radiology · 2024Article
- Breast Cancer in Young Women: Is It Different? A Single-Center Retrospective Cohort Study.Clinical Medicine Insights. Oncology · 2024Article
- Survival probabilities and prognostic factors of pregnancy-associated breast cancer in Malaysian women.Obstetrics & gynecology science · 2024Article
- Review
- Subtype of breast cancer influences sentinel lymph node positivity.Archives of medical science : AMS · 2023Article
- Survey of clinicians on the use of adjuvant therapy for premenopausal women with breast cancer.PloS one · 2023Article
- Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach.International journal of environmental research and public health · 2022Article
- Clinicopathological features and BRCA1 and BRCA2 mutation status in a prospective cohort of young women with breast cancer.British journal of cancer · 2022Article
- Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion.Frontiers in surgery · 2022Article
- Comparing the Prognoses of Breast-Conserving Surgeries for Differently Aged Women with Early Stage Breast Cancer: Use of a Propensity Score Method.The breast journal · 2022Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeAlthough age is a recognized independent prognostic risk factor, its relative importance among molecular subtypes of Breast cancer (BCA) is not well documented. The aim of this study was to evaluate the prognostic role of age at diagnosis among different immunohistochemical subtypes of BCA.
methodsWe conducted a retrospective study of women with invasive BCA undergoing surgery at the Johns Hopkins Hospital, excluding patients presenting with stage IV breast cancer. Patients were stratified into three age groups: ≤ 40, 41-60, and > 60 years, and multivariable analysis was performed using Cox regression. We also identified differentially expressed genes (DEG) between age groups among BCA subtypes in the public TCGA dataset. Finally, we identified key driver genes within the DEGs using a weighted gene co-expression network analysis.
resultsLuminal A breast cancer patients had significantly lower 5 year disease-free survival (DFS) and distant metastasis-free survival (DMFS) in the ≤ 40 year age group compared to the 41-60 year age group, while the other molecular subtypes showed no significant association of DFS or DMFS with age. Age was a stronger outcome predictor than tumor grade or proliferative index in Luminal A BCA patients, but not other subtypes. BCA TCGA gene expression data were divided into two groups (≤ 40 years, > 40 years). We identified 374 DEGs in the Luminal A BCA subset, which were enriched in seven pathways and two modules of co-expressed genes. No age group-specific DEGs were identified in non-Luminal A subtypes.
conclusionsAge at diagnosis may be an important prognostic factor in Luminal A BCA.
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