Evidence map›Paper›PMID 30225539›Full record

ArticleJournal of cancer research and clinical oncology2018

Presence and activity of HPV in primary lung cancer.

Talita Helena Araujo de Oliveira, Carolina Medeiros do Amaral, Bianca de França São Marcos, Kamylla Conceição Gomes Nascimento, Ana Carine de Miranda Rios, Dafne Carolina Alves Quixabeira, Maria Tereza Cartaxo Muniz, Jacinto da Costa Silva Neto, Antonio Carlos de Freitas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Human papillomavirus and lung cancer: an overview and a meta-analysis.Journal of cancer research and clinical oncology · 2019
    Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. [Microassay of High-Risk Human Papillomavirus Genotype Based on R6G-ddATP/SNaPshot-Gel Fluorescence Method].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Article
  17. The Role of Respiratory Microbiota in Lung Cancer.International journal of biological sciences · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Talita Helena Araujo de OliveiraLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil.
Carolina Medeiros do AmaralLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil.
Bianca de França São MarcosMolecular Biology Laboratory, Pediatric Oncohematology Center, University of Pernambuco, Avenida Agamenon Magalhaes S/N, Recife, PE, 50100-130, Brazil.
Kamylla Conceição Gomes NascimentoLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil.
Ana Carine de Miranda RiosLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil.
Dafne Carolina Alves QuixabeiraLaboratory of Cytological and Molecular Research (LPCM), Department of Histology and Embryology, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil.
Maria Tereza Cartaxo MunizMolecular Biology Laboratory, Pediatric Oncohematology Center, University of Pernambuco, Avenida Agamenon Magalhaes S/N, Recife, PE, 50100-130, Brazil.
Jacinto da Costa Silva NetoLaboratory of Cytological and Molecular Research (LPCM), Department of Histology and Embryology, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil.
Antonio Carlos de FreitasLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Avenida Professor Moraes Rego S/N, Recife, PE, 50670-901, Brazil. acf_ufpe@yahoo.com.br.ORCID http://orcid.org/0000-0002-4957-9549
Universidade Federal de Pernambuco · BRUniversidade de Pernambuco · BR

Funding

FACEPE/PRONEM APQ-0562-2.02/14
6 · The paper itself

Abstract

purposeEvaluate the presence of human papillomavirus (HPV) in biopsies of Brazilian patients with lung cancer and also the expression of the E6 and E7 oncoproteins. HPV is widely known as an important condition for cervical cancer although evidence today shows it is associated with several other types of cancer and may also be involved in lung cancer development. However, there are some divergences regarding the presence and activity of HPV in lung carcinogenesis.

methodsThe detection of HPV was performed by PCR, followed by genotype and immunohistochemical evaluation of E6 and E7 HPV type specific, from 63 patients.

resultsHPV was found to be present in 33 of the 63 samples, and types 16 and 18 were detected with frequencies of 81% (27/33) and 19% (6/33), respectively. About the presence of the virus in different histological types of tumors, HPV was detected in squamous cell carcinoma (39.39%), followed by adenocarcinoma (33.33%) and small cell carcinoma (18.18%) and large cell carcinoma (9.1%). The presence of the E6 (antibody anti-HPV 16 and anti-HPV 18) and E7 (antibody anti-HPV 16 and anti-HPV 18) oncoproteins was detected by immunohistochemical stain technique in 28/33 samples and 25/33 samples, respectively.

conclusionsOur results suggest that the lung tumor patients have high prevalence of HPV and the virus is not only present but also active in tumor cells. Therefore, the HPV is probably playing a role in lung carcinogenesis.

Indexed as

PapillomaviridaeAdolescentAdultAgedAged, 80 and overChildFemaleHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedOncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus InfectionsYoung AdultOncogene Proteins, ViralPapillomavirus E7 ProteinsCarcinogenesisHuman PapillomavirusLung carcinomaOncoproteins

Identifiers

PMID30225539
PMCPMC11813451
OpenAlexW2891815305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.