ArticleDiabetologia2018
The impact of maternal gestational weight gain on cardiometabolic risk factors in children.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Energy intake and physical activity over the course of pregnancy and gestational weight gain: a systematic review and dose-response meta-analysis of data from randomized controlled lifestyle intervention trials.Nutrition journal · 2025Pooled it
- Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- Maternal overnutrition impairs offspring's insulin sensitivity: A systematic review and meta-analysis.Maternal & child nutrition · 2020Pooled it
- The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years.Scientific reports · 2021Trial
- Experiences regarding nutrition and exercise among women during early postpartum: a qualitative grounded theory study.BMC pregnancy and childbirth · 2019Trial
- Maternal Body Mass Index, Gestational Weight Gain, and Cardiovascular Disease in Offspring.JAMA network open · 2026Article
- Late Preschool BMI Acceleration as the Strongest Predictor of Childhood Cardiometabolic Risk at School Entry: A Dual-Trajectory Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- From Exposure to Dysfunction: The Intestinal Toxicity of Per- and Polyfluoroalkyl Substances.Toxics · 2025Review
- Cardiac Aftermath of Gestational Diabetes-From Intrauterine Impact to Lifelong Complications: A Systematic Review.Journal of developmental biology · 2025Review
- Article
- Maternal Nutrient Excess Induces Stress Signaling and Decreases Mitochondrial Number in Term Fetal Baboon Skeletal Muscle.Biology · 2025Article
- Contributions of subjective status to eating behaviors, obesity, and metabolic health across development.Appetite · 2025Review
- Associations Between Gestational Weight Gain, Gestational Diabetes, and Childhood Obesity Incidence.Maternal and child health journal · 2024Article
- In Vitro Circadian Clock Gene Expression Assessments in Mesenchymal Stem Cells from Human Infants: A Pilot Study.Nutrients · 2023Article
- Higher gestational weight gain delays wound healing and reduces expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells.The Journal of physiology · 2023Article
- Weight progression and adherence to weight gain target in women with vs. without gestational diabetes: a retrospective cohort study.BMC pregnancy and childbirth · 2023Article
- The roles of newborn anthropometrics in the association between maternal weight gain and childhood cardiovascular risks.Obesity (Silver Spring, Md.) · 2022Article
- A Lifestyle Intervention During Pregnancy and Its Effects on Child Weight 2.5 Years Later.Maternal and child health journal · 2022Article
- Vitamin D Levels During Pregnancy Are Associated With Offspring Telomere Length: A Longitudinal Mother-Child Study.The Journal of clinical endocrinology and metabolism · 2022Observational
- Insufficient weight management in pregnant women with gestational diabetes mellitus.Osong public health and research perspectives · 2022Article
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11 authors.
Funding
Abstract
aims/hypothesisAccumulating evidence suggests an impact of gestational weight gain (GWG) on pregnancy outcomes; however, data on cardiometabolic risk factors later in life have not been comprehensively studied. This study aimed to evaluate the relationship between GWG and cardiometabolic risk in offspring aged 7 years.
methodsWe included a total of 905 mother-child pairs who enrolled in the follow-up visit of the multicentre Hyperglycemia and Adverse Pregnancy Outcome study, at the Hong Kong Centre. Women were classified as having gained weight below, within or exceeding the 2009 Institute of Medicine (IOM) guidelines. A standardised GWG according to pre-pregnancy BMI categories was calculated to explore for any quadratic relationship.
resultsIndependent of pre-pregnancy BMI, gestational hyperglycaemia and other confounders, women who gained more weight than the IOM recommendations had offspring with a larger body size and increased odds of adiposity, hypertension and insulin resistance (range of p values of all the traits: 4.6 × 10 CONCLUSIONS/
interpretationBoth excessive and inadequate GWG have independent and significant impacts on childhood adiposity, hypertension and insulin resistance. Our findings support the notion that adverse intrauterine exposures are associated with persistent cardiometabolic risk in the offspring.
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