ArticleeNeuro
Parallel Arousal Pathways in the Lateral Hypothalamus.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Construction of complex memories via parallel distributed cortical-subcortical iterative integration.Trends in neurosciences · 2022Review
- Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling.Frontiers in physiology · 2022Article
- Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats.Journal of cannabis research · 2021Article
- Characterization of mWake expression in the murine brain.The Journal of comparative neurology · 2021Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Until recently, hypocretin (Hcrt) neurons were the only known wake-promoting neuronal population in the lateral hypothalamus (LH), but subpopulations of inhibitory neurons in this area and glutamatergic neurons in the nearby supramammillary nucleus (SuM) have recently been found that also promote wakefulness. We performed chemogenetic excitation of LH neurons in mice and observed increased wakefulness that lasted more than 4 h without unusual behavior or EEG anomalies. The increased wakefulness was similar in the presence or absence of the dual orexin receptor blocker almorexant (ALM). Analysis of hM3Dq transfection and c-FOS expression in LH inhibitory neurons and in the SuM failed to confirm that the increased wakefulness was due to these wake-promoting populations, although this possibility cannot be completely excluded. To evaluate the relationship to the Hcrt system, we repeated the study in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.