Evidence map›Paper›PMID 30225359›Full record

ArticleeNeuro

Myelination of Axons Corresponds with Faster Transmission Speed in the Prefrontal Cortex of Developing Male Rats.

Sean McDougall, Wanette Vargas Riad, Andrea Silva-Gotay, Elizabeth R Tavares, Divya Harpalani, Geng-Lin Li, Heather N Richardson

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Graded Variation in T1w/T2w Ratio during Adolescence: Measurement, Caveats, and Implications for Development of Cortical Myelin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  15. Cognition, mood and behavior in CADASIL.Cerebral circulation - cognition and behavior · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sean McDougallDepartment of Psychological and Brain Sciences.ORCID 0000-0002-8392-0675
Wanette Vargas RiadNeuroscience and Behavior Graduate Program.
Andrea Silva-GotayNeuroscience and Behavior Graduate Program.ORCID 0000-0002-7186-7248
Elizabeth R TavaresDepartment of Psychological and Brain Sciences.
Divya HarpalaniDepartment of Psychological and Brain Sciences.
Geng-Lin LiBiology Department, University of Massachusetts, Amherst, MA 01003.ORCID 0000-0001-7053-4284
Heather N RichardsonDepartment of Psychological and Brain Sciences.ORCID 0000-0001-7659-1212

Funding

UMass Amherst PREP ProgramR25GM086264 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PEYTON, SHELLY R., RICHARDSON, HEATHER NOËL · 2009 to 2023
$4.7M
Adolescent binge drinking and effects on adult brain and behavior: the importance of sex differencesR01AA024774 · NIAAA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI RICHARDSON, HEATHER NOËL · 2016 to 2020
$1.8M
High-fidelity synaptic transmission from hair cells to auditory afferent fibersR01DC015475 · NIDCD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI LI, GENG-LIN · 2017 to 2019
$794k
Auditory Coding at the Hair Cell Ribbon SynapseR00DC010198 · NIDCD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI LI, GENG-LIN · 2012 to 2014
$735k
Effect of Voluntary Binge Drinking on the Prefrontal Cortex in Adolescent RatsR21AA021013 · NIAAA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI RICHARDSON, HEATHER NOËL · 2012 to 2013
$380k
NIAAA NIH HHS R01 AA024774NIAAA NIH HHS R21 AA021013NIDCD NIH HHS R00 DC010198NIDCD NIH HHS R01 DC015475
6 · The paper itself

Abstract

Myelination of prefrontal circuits during adolescence is thought to lead to enhanced cognitive processing and improved behavioral control. However, while standard neuroimaging techniques commonly used in human and animal studies can measure large white matter bundles and residual conduction speed, they cannot directly measure myelination of individual axons or how fast electrical signals travel along these axons. Here we focused on a specific population of prefrontal axons to directly measure conduction velocity and myelin microstructure in developing male rats. An

Indexed as

Action PotentialsAge FactorsAnimalsAxonsCorpus CallosumGyrus CinguliMaleMyelin SheathNeural ConductionPatch-Clamp TechniquesPrefrontal CortexRatsRats, Wistaranterior cingulateconduction velocityforceps minorg-ratiomyelin whole-cell patch clamp

Identifiers

PMID30225359
PMCPMC6140121

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.