Evidence map›Paper›PMID 30225353›Full record

ArticleeNeuro

The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons.

Rhalena A Thomas, Julien Gibon, Carol X Q Chen, Sabrina Chierzi, Vincent G Soubannier, Stephanie Baulac, Philippe Séguéla, Keith Murai, Philip A Barker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic KNeurology(R) neuroimmunology & neuroinflammation · 2024
    Article
  6. Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rhalena A ThomasDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Julien GibonDepartment of Biology, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.ORCID 0000-0001-7216-5806
Carol X Q ChenDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Sabrina ChierziDepartment of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3H2R9, Canada.
Vincent G SoubannierDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Stephanie BaulacUniversité Pierre-et-Marie-Curie Université Paris 06, Sorbonne Universités, Paris, 75005, France; Institut National de la Santé et de la Recherche Médicale, Unité 1127, Paris, 75006, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France; Institut du Cerveau et de la Moelle Épinière), Paris, 75006, France; Groupe Hospitalier Pitié-Salpêtrière, Paris, 75013, France.
Philippe SéguélaDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Keith MuraiDepartment of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3H2R9, Canada.
Philip A BarkerDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Montreal Neurological Institute and Hospital · CAMontreal General Hospital · CASorbonne Université · FRUniversity of British Columbia · CA

Funding

CIHR 130239CIHR 37850
6 · The paper itself

Abstract

Leucine-rich glioma-inactivated protein 1 (LGI1) is a secreted neuronal protein and a Nogo receptor 1 (NgR1) ligand. Mutations in LGI1 in humans causes autosomal dominant lateral temporal lobe epilepsy and homozygous deletion of LGI1 in mice results in severe epileptic seizures that cause early postnatal death. NgR1 plays an important role in the development of CNS synapses and circuitry by limiting plasticity in the adult cortex via the activation of RhoA. These relationships and functions prompted us to examine the effect of LGI1 on synapse formation

Indexed as

AnimalsEmbryo, MammalianEpilepsyExcitatory Postsynaptic PotentialsFemaleHippocampusIntracellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutNeocortexNeuronal PlasticityNeuronsNogo Receptor 1Patch-Clamp TechniquesProteinsIntracellular Signaling Peptides and ProteinsLgi1 protein, mouseNogo Receptor 1ProteinsReceptors, Tumor Necrosis FactorrhoA GTP-Binding ProteinRhoA protein, mouserho GTP-Binding ProteinsRtn4r protein, mouseTnfrsf19 protein, mouseepilepsyleucine-rich glioma-inactivated gene 1RhoAsynaptic activitysynaptic plasticityTROY

Identifiers

PMID30225353
PMCPMC6140115
OpenAlexW2889318569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.