ArticleeNeuro
Visual Temporal Contrast Sensitivity in the Behaving Mouse Shares Fundamental Properties with Human Psychophysics.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects.iScience · 2026Article
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- Retinal Cx36 gap junctions in the inner and outer plexiform layers differentially control visual thresholds.iScience · 2026Article
- Disruptions in primary visual cortex physiology and function in a mouse model of Timothy syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Signal Detection Theoretic Estimates of the Murine Absolute Visual Threshold Are Independent of Decision Bias.eNeuro · 2024Article
- Mammals Achieve Common Neural Coverage of Visual Scenes Using Distinct Sampling Behaviors.eNeuro · 2024Article
- A Review of Cervidae Visual Ecology.Animals : an open access journal from MDPI · 2024Review
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- Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Color and contrast vision in mouse models of aging and Alzheimer's disease using a novel visual-stimuli four-arm maze.Scientific reports · 2021Article
- Rod Photoreceptors Signal Fast Changes in Daylight Levels Using a Cx36-Independent Retinal Pathway in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Contrast-Dependence of Temporal Frequency Tuning in Mouse V1.Frontiers in neuroscience · 2020Article
- Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian visual system has a remarkable capacity to detect differences in contrast across time, which is known as temporal contrast sensitivity (TCS). Details of the underlying neural mechanisms are rapidly emerging as a result of a series of elegant electrophysiological studies performed largely with the mouse as an experimental model. However, rigorous psychophysical methods are necessary to pair the electrophysiology with temporal visual behavior in mouse. The optomotor response is frequently used as a proxy for retinal temporal processing in rodents. However, subcortical reflexive pathways drive the optomotor response rather than cortical decision-making areas. To address this problem, we have developed an operant behavior assay that measures TCS in behaving mice. Mice were trained to perform a forced-choice visual task and were tested daily on their ability to distinguish flickering from nonflickering overhead lights. Correct responses (Hit and Correct Rejections) were rewarded. Contrast, temporal frequency, and mean illumination of the flicker were the independent variables. We validated and applied the theory of signal detection to estimate the discriminability factor (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.