ArticlePhotoacoustics2018
Simultaneous ultra-high frequency photoacoustic microscopy and photoacoustic radiometry of zebrafish larvae
Article in Photoacoustics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Polydopamine Nanoparticles as Label-Free Contrast Agents in Photoacoustic ImagingACS applied optical materials · 2026Article
- Label-free photoacoustic microscopy: a potential tool for the live imaging of blood disorders in zebrafish.Biomedical optics express · 2021Article
- Anti-HER2 PLGA-PEG polymer nanoparticle containing gold nanorods and paclitaxel for laser-activated breast cancer detection and therapy.Biomedical optics express · 2021Article
- 3D PHOVIS: 3D photoacoustic visualization studio.Photoacoustics · 2020Article
- Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae.Biomedical optics express · 2020Article
- Label-free optical imaging in developmental biology [Invited].Biomedical optics express · 2020Review
- Single-shot photoacoustic microscopy of hemoglobin concentration, oxygen saturation, and blood flow in sub-microseconds.Photoacoustics · 2020Article
- Insights into photoacoustic speckle and applications in tumor characterization.Photoacoustics · 2019Article
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Authors and funding
6 authors.
Funding
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Abstract
With their optically transparent appearance, zebrafish larvae are readily imaged with optical-resolution photoacoustic (PA) microscopy (OR-PAM). Previous OR-PAM studies have mapped endogenous chromophores (e.g. melanin and hemoglobin) within larvae; however, anatomical features cannot be imaged with OR-PAM alone due to insufficient optical absorption. We have previously reported on the photoacoustic radiometry (PAR) technique, which can be used simultaneously with OR-PAM to generate images dependent upon the optical attenuation properties of a sample. Here we demonstrate application of the duplex PAR/PA technique for label-free imaging of the anatomy and vasculature of zebrafish larvae in vivo at 200 and 400 MHz ultrasound detection frequencies. We then use the technique to assess the effects of anti-angiogenic drugs on the development of the larval vasculature. Our results demonstrate the effectiveness of simultaneous PAR/PA for acquiring anatomical images of optically transparent samples in vivo, and its potential applications in assessing drug efficacy and embryonic development.
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