Evidence map›Paper›PMID 30225184›Full record

ArticleCurrent behavioral neuroscience reports2018

Traumatic Stress Epigenetics.

John R Pfeiffer, Leon Mutesa, Monica Uddin

Open access · greenAbstract read
In one paragraph

Article in Current behavioral neuroscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Epigenetics, Resilience, Protective Factors and Factors Promoting Positive Outcomes: A Scoping Review.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025
    Article
  2. Review
  3. Epigenetic analyses in forensic medicine: future and challenges.International journal of legal medicine · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

John R PfeifferDepartment of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Leon MutesaCenter for Human Genetics, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda.
Monica UddinDepartment of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
University of Illinois Urbana-Champaign · USUniversity of Rwanda · RWUrbana University · US

Funding

The Impact of Traumatic Stress on the Methylome: implications for PTSDR01MH108826 · NIMH · EMORY UNIVERSITY · PI LOGUE, MARK W, NIEVERGELT, CAROLINE M · 2016 to 2024
$5.8M
Transgenerational Epigenomics of Trauma and PTSD in RwandaU01MH115485 · NIMH · NATIONAL UNIVERSITY OF RWANDA · PI JANSEN, STEFAN, MUTESA, LEON · 2017 to 2021
$1.3M
NIMH NIH HHS R01 MH108826NIMH NIH HHS U01 MH115485
6 · The paper itself

Abstract

purpose of reviewTraumatic stress has profound impacts on many domains of life, yet the mechanisms that confer risk for or resilience to the development of traumatic stress-related psychopathologies are still very much under investigation. The current review highlights recent developments in the field of traumatic stress epigenetics in humans. RECENT

findingsRecent results reveal traumatic stress-related epigenetic dysregulation in neural, endocrine, and immune system genes and associated networks. Emerging work combining imaging with epigenetic measures holds promise for addressing the correspondence between peripheral and central effects of traumatic stress. A growing literature is also documenting the transgenerational effects of prenatal stress exposures in humans. SUMMARY: Moving forward, increasing focus on epigenetic marks of traumatic stress in CNS tissue will create a clearer picture of the relevance of peripheral measures; PTSD brain banks will help in this regard. Similarly, leveraging multigenerational birth cohort data will do much to clarify the extent of transgenerational epigenetic effects of traumatic stress. Greater efforts should be made towards developing prospective studies with longitudinal design.

Indexed as

DNA methylationHumanNeuroimagingPeripheral tissueTransgenerational

Identifiers

PMID30225184
PMCPMC6138446
OpenAlexW2790617575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.