ArticleIUCrJ2018
Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome.
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Article in IUCrJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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32 citing papers in PubMed, 49 citations in OpenAlex.
- A simple and practical approach for protein serial crystallography using grease matrix and large-area support film.Journal of synchrotron radiation · 2026Article
- A bacteriophytochrome Pr/Pfr heterodimer studied through single-particle time-resolved cryo-electron microscopy.Communications chemistry · 2026Article
- Structures of Myxobacterial Phytochrome Revealed by Cryo-EM.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Milestones in the development ofJournal of bacteriology · 2025Review
- Pr and Pfr structures of plant phytochrome A.Nature communications · 2025Article
- Observation of early events in the photoactivation of Myxobacterial phytochrome using time-resolved serial femtosecond crystallography.Communications chemistry · 2025Article
- Structures of myxobacterial phytochrome revealed by cryo-EM using the Spotiton technique and with x-ray crystallography.Structural dynamics (Melville, N.Y.) · 2025Article
- Interaction between bacterial phytochromes Agp1 and Agp2 of Agrobacterium fabrum by fluorescence resonance energy transfer and docking studies.FEBS letters · 2025Article
- Dual-Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?The FEBS journal · 2025Article
- Phytochrome-mediated shade avoidance responses impact the structure and composition of the bacterial phyllosphere microbiome of Arabidopsis.Environmental microbiome · 2025Article
- Exploiting fourth-generation synchrotron radiation for enzyme and photoreceptor characterization.IUCrJ · 2025Article
- Photomorphogenesis of Myxococcus macrosporus: new insights for light-regulation of cell development.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Photoreception and signaling in bacterial phytochrome revealed by single-particle cryo-EM.Science advances · 2024Article
- Blue and red in the protein world: Photoactive yellow protein and phytochromes as revealed by time-resolved crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- Development of bright red-shifted miRFP704nano using structural analysis of miRFPnano proteins.Protein science : a publication of the Protein Society · 2023Article
- The structure of Arabidopsis phytochrome A reveals topological and functional diversification among the plant photoreceptor isoforms.Nature plants · 2023Article
- Protein control of photochemistry and transient intermediates in phytochromes.Nature communications · 2022Article
- The structural effect between the output module and chromophore-binding domain is a two-way street via the hairpin extension.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Conserved histidine and tyrosine determine spectral responses through the water network in Deinococcus radiodurans phytochrome.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Protein-chromophore interactions controlling photoisomerization in red/green cyanobacteriochromes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
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Authors and funding
41 authors at 12 institutions in 4 countries.
Nicole C WoitowichDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Andrei S HalavatyDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Patricia WaltzDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Christopher KupitzDepartment of Physics, University of Wisconsin, Milwaukee, WI, USA.
Joseph ValeraDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Gregory TracyDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Kevin D GallagherDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Elin ClaessonDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.
Takanori NakaneDepartment of Biological Sciences, Graduate School of Science, University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.ORCID https://orcid.org/0000-0003-2697-2767
Suraj PandeyDepartment of Physics, University of Wisconsin, Milwaukee, WI, USA.
Garrett NelsonCenter for Applied Structural Discovery, Arizona State University, 85287 Tempe, AZ, USA.ORCID https://orcid.org/0000-0003-4008-8257
Rie TanakaRIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, 679-5148 Hyogo, Japan.ORCID https://orcid.org/0000-0003-1062-4792
Eriko NangoRIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, 679-5148 Hyogo, Japan.ORCID https://orcid.org/0000-0001-9851-7355
Eiichi MizohataDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID https://orcid.org/0000-0002-5526-5343
Shigeki OwadaRIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, 679-5148 Hyogo, Japan.ORCID https://orcid.org/0000-0002-1451-7612
Kensure TonoRIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, 679-5148 Hyogo, Japan.ORCID https://orcid.org/0000-0003-1218-3759
Yasumasa JotiRIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, 679-5148 Hyogo, Japan.ORCID https://orcid.org/0000-0002-4040-5972
Angela C NugentDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Hardik PatelDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-9999-9605
Ayesha MaparaDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
James HopkinsDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.ORCID https://orcid.org/0000-0003-3552-2629
Phu DuongDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Dorina BizhgaDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Svetlana E KovalevaDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-8878-9189
Rachael St PeterDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-3379-9352
Cynthia N HernandezDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Wesley B OzarowskiDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Shatabdi Roy-ChowdhuriCenter for Applied Structural Discovery, Arizona State University, 85287 Tempe, AZ, USA.
Jay-How YangCenter for Applied Structural Discovery, Arizona State University, 85287 Tempe, AZ, USA.
Petra EdlundDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-5746-8857
Heikki TakalaFaculty of Medicine, Anatomy, University of Helsinki, 00014 Helsinki, Finland.ORCID https://orcid.org/0000-0003-2518-8583
Janne IhalainenNanoscience Center, Department of Biological and Environmental Sciences, University of Jyvaskyla, 40014 Jyvaskyla, Finland.ORCID https://orcid.org/0000-0002-8741-1587
Jennifer BrayshawDepartment of Physics, University of Wisconsin, Milwaukee, WI, USA.
Tyler NorwoodDepartment of Physics, University of Wisconsin, Milwaukee, WI, USA.
Ishwor PoudyalDepartment of Physics, University of Wisconsin, Milwaukee, WI, USA.
Petra FrommeCenter for Applied Structural Discovery, Arizona State University, 85287 Tempe, AZ, USA.
John C H SpenceCenter for Applied Structural Discovery, Arizona State University, 85287 Tempe, AZ, USA.ORCID https://orcid.org/0000-0001-6049-3925
Keith MoffatDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-7417-9264
Sebastian WestenhoffDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-6961-8015
Marius SchmidtDepartment of Physics, University of Wisconsin, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0002-0962-9468
Emina A StojkovićDepartment of Biology, Northeastern Illinois University, Chicago, IL, USA.
Northeastern Illinois University · USUniversity of Wisconsin–Milwaukee · USArizona State University · USSPring-8 · JPUniversity of Gothenburg · SEKyoto University · JPNorthwestern University · USThe University of Osaka · JPThe University of Tokyo · JPUniversity of Chicago · USUniversity of Helsinki · FIUniversity of Jyväskylä · FI
Funding
Femtosecond nano-crystallography of membrane proteinsR01GM095583 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI FROMME, PETRA · 2010 to 2023
$4.3MStructures, Dynamics and Signaling Mechanisms of Modular PhotoreceptorsR01EY024363 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YANG, XIAOJING · 2014 to 2021
$2.9MNU-STARS for Northeastern Illinois Student Training in Academic Research in the SciencesT34GM105549 · NIGMS · NORTHEASTERN ILLINOIS UNIVERSITY · PI CHURCH, RUTH B, HIBDON, JOSEPH EDWARD · 2014 to 2023
$2.8MEuropean Research Council 279944NEI NIH HHS R01 EY024363NIGMS NIH HHS R01 GM095583NIGMS NIH HHS T34 GM105549
Abstract
Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states denoted Pr and Pfr with distinct absorption spectra in the red and far-red. They have recently been engineered as enzymatic photoswitches for fluorescent-marker applications in non-invasive tissue imaging of mammals. This article presents cryo- and room-temperature crystal structures of the unusual phytochrome from the non-photosynthetic myxo-bacterium
Indexed as
absorption spectramyxobacteriaphotoreceptorsphotosynthetic bacteriaphytochromes
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