Evidence map›Paper›PMID 30224799›Full record

ArticleNature microbiology2018

Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors.

Hui Sun, Jana Kamanova, Maria Lara-Tejero, Jorge E Galán

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  5. The interplay betweenCell insight · 2025
    Review
  6. International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Tropical medicine and infectious disease · 2023
    Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hui SunDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Jana KamanovaDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6574-4404
Maria Lara-TejeroDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
Jorge E GalánDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA. jorge.galan@yale.edu.ORCID http://orcid.org/0000-0002-6531-0355
Yale University · US

Funding

Host Cell Signaling Pathways Induced By SalmonellaR01AI055472 · NIAID · YALE UNIVERSITY · PI Jorge E Galan · 2003 to 2026
$13.2M
Typhoid Toxin and Salmonella Typhi pathogenesisR01AI114618 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2014 to 2023
$5.4M
NIAID NIH HHS R01 AI055472NIAID NIH HHS R01 AI114618
6 · The paper itself

Abstract

Microbial infections are most often countered by inflammatory responses that are initiated through the recognition of conserved microbial products by innate immune receptors and result in pathogen expulsion

Indexed as

AnimalsBacterial Loadcdc42 GTP-Binding ProteinCells, CulturedHost-Pathogen InteractionsHumansImmunity, InnateIntestinesMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMiceNF-kappa Bp21-Activated KinasesPhosphorylationSalmonella InfectionsSalmonella typhimuriumcdc42 GTP-Binding ProteinMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesNF-kappa Bp21-Activated KinasesTNF Receptor-Associated Factor 6Type III Secretion Systems

Identifiers

PMID30224799
PMCPMC6158040
OpenAlexW2889919580

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.