ArticleNature microbiology2018
Structural basis of the arbitrium peptide-AimR communication system in the phage lysis-lysogeny decision.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Review of the Arbitrium (ARM) System: Molecular Mechanisms, Ecological Impacts, and Applications in Phage-Host Communication.Microorganisms · 2025Review
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances.Journal of pharmaceutical analysis · 2024Review
- Arbitrium communication controls phage lysogeny through non-lethal modulation of a host toxin-antitoxin defence system.Nature microbiology · 2024Article
- Structural and functional characterization of MrpR, the master repressor of the Bacillus subtilis prophage SPβ.Nucleic acids research · 2023Article
- Cellular and Natural Viral Engineering in Cognition-Based Evolution.Communicative & integrative biology · 2023Review
- Article
- Mining bacterial NGS data vastly expands the complete genomes of temperate phages.NAR genomics and bioinformatics · 2022Article
- Insights into the mechanism of action of the arbitrium communication system in SPbeta phages.Nature communications · 2022Article
- Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review.Pharmaceutics · 2022Review
- Dormant phages communicate via arbitrium to control exit from lysogeny.Nature microbiology · 2022Article
- AimR Adopts Preexisting Dimer Conformations for Specific Target Recognition in Lysis-Lysogeny Decisions ofBiomolecules · 2021Article
- The impact of quorum sensing on the modulation of phage-host interactions.Journal of bacteriology · 2021Review
- Characterization of lytic activity ofJournal of advanced veterinary and animal research · 2020Article
- Quorum Sensing Signals AlterFrontiers in microbiology · 2020Article
- The secret social lives of viruses.Nature · 2019Article
- Widespread Utilization of Peptide Communication in Phages Infecting Soil and Pathogenic Bacteria.Cell host & microbe · 2019Article
- Deciphering the Molecular Mechanism Underpinning Phage Arbitrium Communication Systems.Molecular cell · 2019Article
- Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages.Protein & cell · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A bacteriophage can replicate and release virions from a host cell in the lytic cycle or switch to a lysogenic process in which the phage integrates itself into the host genome as a prophage. In Bacillus cells, some types of phages employ the arbitrium communication system, which contains an arbitrium hexapeptide, the cellular receptor AimR and the lysogenic negative regulator AimX. This system controls the decision between the lytic and lysogenic cycles. However, both the mechanism of molecular recognition between the arbitrium peptide and AimR and how downstream gene expression is regulated remain unknown. Here, we report crystal structures for AimR from the SPbeta phage in the apo form and the arbitrium peptide-bound form at 2.20 Å and 1.92 Å, respectively. With or without the peptide, AimR dimerizes through the C-terminal capping helix. AimR assembles a superhelical fold and accommodates the peptide encircled by its tetratricopeptide repeats, which is reminiscent of RRNPP family members from the quorum-sensing system. In the absence of the arbitrium peptide, AimR targets the upstream sequence of the aimX gene; its DNA binding activity is prevented following peptide binding. In summary, our findings provide a structural basis for peptide recognition in the phage lysis-lysogeny decision communication system.
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