ReviewNature reviews. Nephrology2018
Maternal and environmental risk factors for neonatal AKI and its long-term consequences.
Review in Nature reviews. Nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy.Journal of nephrology · 2022Pooled it
- Risk Factors for Acute Kidney Injury in Critically Ill Neonates: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Acute kidney injury and early mortality in extremely preterm neonates born at 22-27 weeks gestation.Pediatric nephrology (Berlin, Germany) · 2026Article
- Incidence, Predictors, and Outcomes Associated with Recurrent Neonatal Acute Kidney Injury in Preterm Infants: A Secondary Analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT).Research square · 2026Article
- Kidney health and blood pressure after very preterm birth: a cohort study at school age.Pediatric nephrology (Berlin, Germany) · 2026Article
- The global epidemiology of acute kidney injury: challenges and opportunities.Nature reviews. Nephrology · 2026Review
- The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets.Biomedicines · 2026Review
- Clinical Determinants and Mortality Predictors of Acute Kidney Injury in Neonates: A Five-Year Retrospective Cohort Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Molecular frontiers in hemodialysis: unraveling the role of membranes in gene expression, epigenetics, and inflammatory pathways.International urology and nephrology · 2025Review
- The overlooked subgroup: preterm neonates with elevated serum creatinine outside neonatal AKI criteria.Pediatric research · 2025Article
- Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway.Inflammation · 2025Article
- The challenges for developing prognostic prediction models for acute kidney injury in hospitalized children: A systematic review.Pediatric investigation · 2025Review
- Lupus nephritis-related chronic kidney disease.Nature reviews. Rheumatology · 2024Review
- Genetic and Clinical Factors Influencing Congenital Anomalies of the Kidney and Urinary Tract in Children: Insights from Prenatal and Postnatal Assessments.Biomedicines · 2024Article
- Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark.Pediatric nephrology (Berlin, Germany) · 2024Article
- Adolescent Kidney Outcomes after Extremely Preterm Birth and Neonatal Acute Kidney Injury: There May be More to the Story.American journal of perinatology · 2024Article
- Low incidence of acute kidney injury in VLBW infants with restrictive use of mechanical ventilation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study.American journal of perinatology · 2024Article
- Recurrent neonatal acute kidney injury: incidence, predictors, and outcomes in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Acute Kidney Injury among Neonates with Perinatal Asphyxia in a Tertiary Care Centre.JNMA; journal of the Nepal Medical Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a common and life-threatening complication in critically ill neonates. Gestational risk factors for AKI include premature birth, intrauterine growth restriction and low birthweight, which are associated with poor nephron development and are often the consequence of pre-gestational and gestational factors, such as poor nutritional status. Our understanding of how to best optimize renal development and prevent AKI is in its infancy; however, the identification of pre-gestational and gestational factors that increase the risk of adverse neonatal outcomes and the implementation of interventions, such as improving nutritional status early in pregnancy, have the potential to optimize fetal growth and reduce the risk of preterm birth, thereby improving kidney health. The overall risk of AKI among critically ill and premature neonates is exacerbated postnatally as these infants are often exposed to dehydration, septic shock and potentially nephrotoxic medications. Strategies to improve outcomes - for example, through careful evaluation of nephrotoxic drugs - may reduce the incidence of AKI and its consequences among this population. Management strategies and updated technology that will support neonates with AKI are greatly needed. Extremely premature infants and those who survive an episode of AKI should be screened for chronic kidney disease until early adulthood. Here, we provide an overview of our current understanding of neonatal AKI, focusing on its relationship to preterm birth and growth restriction. We describe factors that prevent optimal nephrogenesis during pregnancy and provide a framework for future explorations designed to maximize outcomes in this vulnerable population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.