Evidence map›Paper›PMID 30224760›Full record

ArticleNature cell biology2018

Single particle trajectories reveal active endoplasmic reticulum luminal flow.

David Holcman, Pierre Parutto, Joseph E Chambers, Marcus Fantham, Laurence J Young, Stefan J Marciniak, Clemens F Kaminski, David Ron, Edward Avezov

Open access · greenAbstract read
In one paragraph

Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 105 citations in OpenAlex.

  1. Review
  2. Article
  3. Volumetric Single-Molecule Tracking Inside Subcellular Structures.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Endoplasmic Reticulum and Its Contacts: Emerging Roles in Axon Development, Neurotransmission, and Degeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  11. Luminal transport through intact endoplasmic reticulum limits the magnitude of localized CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

David HolcmanGroup of Applied Mathematics and Computational Biology, Ecole Normale Superieure, IBENS, Paris, France. david.holcman@ens.fr.ORCID http://orcid.org/0000-0001-9854-5014
Pierre ParuttoGroup of Applied Mathematics and Computational Biology, Ecole Normale Superieure, IBENS, Paris, France.
Joseph E ChambersCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Marcus FanthamDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Laurence J YoungDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Stefan J MarciniakCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Clemens F KaminskiDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5194-0962
David RonCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3014-5636
Edward AvezovCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. ea347@cam.ac.uk.ORCID http://orcid.org/0000-0002-2894-0585
University of Cambridge · GBÉcole Normale Supérieure - PSL · FR

Funding

Biotechnology and Biological Sciences Research Council BB/H023917/1Medical Research Council G0601840Medical Research Council G0902243Medical Research Council G1002610Medical Research Council MR/K015850/1Medical Research Council MR/K02292X/1Medical Research Council MR/R009120/1
6 · The paper itself

Abstract

The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell

Indexed as

AnimalsCell TrackingChlorocebus aethiopsCOS CellsEndoplasmic ReticulumFluorescence Resonance Energy TransferHEK293 CellsHumansLuminescent ProteinsMicroscopy, FluorescenceProteinsProtein TransportLuminescent ProteinsProteins

Identifiers

PMID30224760
PMCPMC6435195
OpenAlexW2890216231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.