Evidence map›Paper›PMID 30224749›Full record

ArticleNature2018

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.

Oleksiy Kovtun, Natalya Leneva, Yury S Bykov, Nicholas Ariotti, Rohan D Teasdale, Miroslava Schaffer, Benjamin D Engel, David J Owen, John A G Briggs, Brett M Collins

Open access · greenAbstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 239 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Cargo-Adaptor Cooperation Programs Retromer Coat Architecture.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. The subcellular architecture ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Oleksiy Kovtun *MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Natalya Leneva *Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Yury S BykovMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Nicholas AriottiInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Rohan D TeasdaleInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Miroslava SchafferDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.
Benjamin D EngelDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.
David J OwenCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. djo30@cam.ac.uk.
John A G BriggsMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. jbriggs@mrc-lmb.cam.ac.uk.
Brett M CollinsInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia. b.collins@imb.uq.edu.au.
European Molecular Biology Laboratory · DEMax Planck Institute of Biochemistry · DEUniversity of Cambridge · GBUniversity of Queensland · AUUNSW Sydney · AU

Funding

Medical Research Council MC_UP_1201/16Wellcome Trust 207455Wellcome Trust 207455/Z/17/Z
6 · The paper itself

Abstract

Eukaryotic cells traffic proteins and lipids between different compartments using protein-coated vesicles and tubules. The retromer complex is required to generate cargo-selective tubulovesicular carriers from endosomal membranes

Indexed as

Cryoelectron MicroscopyElectron Microscope TomographyChaetomiumChlamydomonas reinhardtiiHumansModels, MolecularProtein BindingProtein TransportSorting NexinsVesicular Transport ProteinsSNX3 protein, humanSorting NexinsVesicular Transport ProteinsVPS26A protein, humanVPS29 protein, humanVPS35 protein, human

Identifiers

PMID30224749
PMCPMC6173284
OpenAlexW2889632501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.