ArticleScientific reports2018
An incoherent feed-forward loop switches the Arabidopsis clock rapidly between two hysteretic states.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Modelling the short-term response to nitrogen that coordinates events in lateral root initiation.Quantitative plant biology · 2026Article
- Receptor kinase pathway signal tuning through a nontranscriptional incoherent feedforward loop.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decoding the plant clock: a review of mathematical models for the circadian regulatory network.Plant molecular biology · 2024Review
- Unlocking Nature's Rhythms: Insights into Secondary Metabolite Modulation by the Circadian Clock.International journal of molecular sciences · 2024Review
- The distribution of fitness effects during adaptive walks using a simple genetic network.PLoS genetics · 2024Article
- Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops.Planta · 2024Review
- Localization of Noise in Biochemical Networks.ACS omega · 2023Article
- The 1972 Meadows report: A wake-up call for plant science.Quantitative plant biology · 2023Article
- WRKY2 and WRKY10 regulate the circadian expression ofPlant communications · 2022Article
- Noise suppression in stochastic genetic circuits using PID controllers.PLoS computational biology · 2021Article
- Article
- Basal leakage in oscillation: Coupled transcriptional and translational control using feed-forward loops.PLoS computational biology · 2020Article
- Light Perception: A Matter of Time.Molecular plant · 2020Review
- Gene Regulatory Network Inference: Connecting Plant Biology and Mathematical Modeling.Frontiers in genetics · 2020Review
- Continuous dynamic adjustment of the plant circadian oscillator.Nature communications · 2019Review
- Hierarchical and Dynamic Regulation of Defense-Responsive Specialized Metabolism by WRKY and MYB Transcription Factors.Frontiers in plant science · 2019Article
- Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.PLoS computational biology · 2019Article
- Emergent robust oscillatory dynamics in the interlocked feedback-feedforward loops.IET systems biologyArticle
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4 authors.
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Abstract
In higher plants (e.g., Arabidopsis thaliana), the core structure of the circadian clock is mostly governed by a repression process with very few direct activators. With a series of simplified models, we studied the underlying mechanism and found that the Arabidopsis clock consists of type-2 incoherent feed-forward loops (IFFLs), one of them creating a pulse-like expression in PRR9/7. The double-negative feedback loop between CCA1/LHY and PRR5/TOC1 generates a bistable, hysteretic behavior in the Arabidopsis circadian clock. We found that the IFFL involving PRR9/7 breaks the bistability and moves the system forward with a rapid pulse in the daytime, and the evening complex (EC) breaks it in the evening. With this illustration, we can intuitively explain the behavior of the clock under mutant conditions. Thus, our results provide new insights into the underlying network structures of the Arabidopsis core oscillator.
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