Evidence map›Paper›PMID 30224694›Full record

ArticleNature chemical biology2018

Post-translational site-selective protein backbone α-deuteration.

Sébastien R G Galan, James R Wickens, Jitka Dadova, Wai-Lung Ng, Xinglong Zhang, Robert A Simion, Robert Quinlan, Elisabete Pires, Robert S Paton, Stephen Caddick and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Sébastien R G GalanChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
James R WickensChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Jitka DadovaChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Wai-Lung NgChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2892-6318
Xinglong ZhangChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1698-692X
Robert A SimionChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Robert QuinlanChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Elisabete PiresChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Robert S PatonChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0104-4166
Stephen CaddickDepartment of Chemistry, University College London, London, UK.
Vijay ChudasamaDepartment of Chemistry, University College London, London, UK. v.chudasama@ucl.ac.uk.
Benjamin G DavisChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK. Ben.Davis@chem.ox.ac.uk.ORCID http://orcid.org/0000-0002-5056-407X
University of Oxford · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isotopic replacement has long-proven applications in small molecules. However, applications in proteins are largely limited to biosynthetic strategies or exchangeable (for example, N-H/D) labile sites only. The development of postbiosynthetic, C-

Indexed as

Protein Processing, Post-TranslationalAlanineBinding SitesCysteineDeuterium Exchange MeasurementGreen Fluorescent ProteinsHistonesMass SpectrometryNuclear Magnetic Resonance, BiomolecularProteinsProtein Structure, SecondaryProteomicsSolventsAlanineCysteinedehydroalanineGreen Fluorescent ProteinsHistonesProteinsSolvents

Identifiers

PMID30224694
OpenAlexW2889566684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.