ArticleNature methods2018
Template-free 2D particle fusion in localization microscopy.
Article in Nature methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Single-Step Expansion SMLM Enables Molecular-Resolution Imaging in Cells and Isolated Proteins.Chemical & biomedical imaging · 2026Article
- Towards improved particle reconstruction for single-molecule localization microscopy using geometric deep learning.Bioinformatics advances · 2026Article
- Detecting continuous structural heterogeneity in single molecule localization microscopy data with a point cloud variational auto-encoder.Scientific reports · 2025Article
- Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body.Nature communications · 2025Article
- Super-resolution microscopy for structural biology.Nature methods · 2025Review
- Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy.Nature communications · 2025Article
- ECLiPSE: a versatile classification technique for structural and morphological analysis of 2D and 3D single-molecule localization microscopy data.Nature methods · 2024Article
- TorsinA is essential for neuronal nuclear pore complex localization and maturation.Nature cell biology · 2024Article
- UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope.The Journal of cell biology · 2024Article
- Physically informed Monte Carlo simulation of dual-wedge prism-based spectroscopic single-molecule localization microscopy.Journal of biomedical optics · 2024Article
- Insights into protein structure using cryogenic light microscopy.Biochemical Society transactions · 2023Review
- Detecting continuous structural heterogeneity in single-molecule localization microscopy data.Scientific reports · 2023Article
- Review
- Particle fusion of super-resolution data reveals the unit structure of Nup96 in Nuclear Pore Complex.Scientific reports · 2023Article
- Article
- Quantitative Single-Molecule Localization Microscopy.Annual review of biophysics · 2023Review
- TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis.bioRxiv : the preprint server for biology · 2023Article
- MINSTED nanoscopy enters the Ångström localization range.Nature biotechnology · 2023Article
- Single molecule imaging simulations with advanced fluorophore photophysics.Communications biology · 2023Article
- Maximum-likelihood model fitting for quantitative analysis of SMLM data.Nature methods · 2023Article
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9 authors.
Funding
Abstract
Methods that fuse multiple localization microscopy images of a single structure can improve signal-to-noise ratio and resolution, but they generally suffer from template bias or sensitivity to registration errors. We present a template-free particle-fusion approach based on an all-to-all registration that provides robustness against individual misregistrations and underlabeling. We achieved 3.3-nm Fourier ring correlation (FRC) image resolution by fusing 383 DNA origami nanostructures with 80% labeling density, and 5.0-nm resolution for structures with 30% labeling density.
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