Evidence map›Paper›PMID 30224653›Full record

SynthesisNature genetics2018

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Evangelos Evangelou, Helen R Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P Cabrera, Ibrahim Karaman and 271 more

Erratum issued Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04331535 (Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care), which is not on this map. Cited by 842 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
842citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
3 · Its place in the literature

Who cites it

842 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  4. Remnant cholesterol and two decades risk of incident hypertension: a prospective cohort study and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Pooled it
  5. Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Pooled it
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782 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

281 authors.

Evangelos EvangelouDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5488-2999
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
David Mosen-AnsorenaDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Borbala MifsudWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Raha PazokiDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
He GaoDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Georgios NtritsosDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Niki DimouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Claudia P CabreraWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ibrahim KaramanDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-9341-8155
Fu Liang NgWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Marina EvangelouDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Katarzyna WitkowskaWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Evan TzanisWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jacklyn N HellwegeDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-7479-0920
Ayush GiriVanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7786-4670
Digna R Velez EdwardsVanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN, USA.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Peter W F WilsonAtlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
Philip S TsaoVA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Csaba P KovesdyNephrology Section, Memphis VA Medical Center and University of Tennessee Health Science Center, Memphis, TN, USA.
Tonu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Peter AlmgrenDepartment Clinical Sciences, Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-0473-0241
Thibaud BoutinMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0003-4754-1675
Stéphanie DebetteDepartment of Neurology, Bordeaux University Hospital, Bordeaux, France.
Jun DingLaboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Elizabeth G HollidayHunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9672-2547
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Wei-Yu LinMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9267-7988
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0002-2167-7470
Christopher OldmeadowHunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Bram Peter PrinsWellcome Trust Sanger Institute, Hinxton, UK.
Yong QianLaboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA.
Muralidharan SargurupremrajUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France.
Nabi ShahDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0003-2764-3615
Praveen SurendranMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Sébastien ThériaultDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Niek VerweijProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Sara M WillemsMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Jing-Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Philippe AmouyelUniversity of Lille, Inserm, Centre Hosp. Univ. Lille, Institut Pasteur de Lille, UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Epidemiology and Public Health Department, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
John ConnellUniversity of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Alex S F DoneyDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0001-9790-0571
Andrew D MorrisUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Raymond NoordamDepartment of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Guillaume ParéDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Neil R PoulterImperial Clinical Trials Unit, London, UK.
Denis C ShieldsSchool of Medicine, University College Dublin, Dublin, Ireland.
Alice StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4961-165X
Simon ThomInternational Centre for Circulatory Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-3020-1351
Gonçalo AbecasisCenter for Statistical Genetics, Department of Biostatistics, SPH II, Washington Heights, Ann Arbor, MI, USA.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Dan E ArkingCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kristin L AyersInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Caterina M BarbieriDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Chiara BatiniDepartment of Health Sciences, University of Leicester, Leicester, UK.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Tineka BlakeDepartment of Health Sciences, University of Leicester, Leicester, UK.
Murielle BochudInstitute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Eric BoerwinkleHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Marco BrumatDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0003-3268-039X
Archie CampbellMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Ganesh ChauhanCentre for Brain Research, Indian Institute of Science, Bangalore, India.
Marina CiulloInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Napoli, Italy.ORCID http://orcid.org/0000-0002-9621-9984
Massimiliano CoccaInstitute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.ORCID http://orcid.org/0000-0002-1127-7596
Francis CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1023-7410
Heather J CordellInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Martin H de BorstDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-4127-8733
Eco J de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Joris DeelenDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-4483-3701
Fabiola Del Greco MInstitute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Cumhur Yusuf DemirkaleMathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Georg B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5730-0675
Roberto ElosuaCIBERCV & Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain.
Stefan EnrothDepartment of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-5056-9137
A Mesut ErzurumluogluDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-1322-8138
Teresa FerreiraWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Mattias FrånbergCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Ilaria GandinDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Paolo GaspariniDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Giorgia GirottoDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0003-4507-6589
Anuj GoelWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2307-4021
Alan J GowCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3320-4531
Vilmundur GudnasonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Tamara B HarrisIntramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Sarah E HarrisMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Aki S HavulinnaDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.ORCID http://orcid.org/0000-0002-4787-8959
Andrew A HicksInstitute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0001-6320-0411
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Albert HofmanDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands.
Jennifer E HuffmanMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0002-9672-2491
Shih-Jen HwangNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Alan JamesDepartment of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, Australia.
Rick JansenDepartment of Psychiatry, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3333-6737
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Roby JoehanesNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-5549-9054
Åsa JohanssonDepartment of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden.
Andrew D JohnsonNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Peter K JoshiCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0002-6361-5059
Pekka JousilahtiDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Antti JulaDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Bernard D KeavneyDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-9573-0812
Kay-Tee KhawDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Paul KnektDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Joanne KnightData Science Institute and Lancaster Medical School, Lancaster, UK.ORCID http://orcid.org/0000-0002-7148-1660
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Jaspal S KoonerMRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Seppo KoskinenDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Kati KristianssonDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.ORCID http://orcid.org/0000-0003-4688-107X
Zoltan KutalikInstitute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8285-7523
Maris LaanInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Marty LarsonNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Lenore J LaunerIntramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
David C M LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0544-7368
Li LinCardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
YongMei LiuDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ruth J F LoosMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0002-8532-5087
Lorna M LopezCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Chrysovalanto MamasoulaInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Jaume MarrugatCIBERCV & Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain.
Jonathan MartenMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands.
Anna MorganDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0001-6290-445X
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Peter J MunsonMathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
Mike A NallsData Tecnica International, Glen Echo, MD, USA.
Priyanka NandakumarCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Teemu NiiranenDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Teresa NutileInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Napoli, Italy.ORCID http://orcid.org/0000-0001-7062-8352
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Ben A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Paul F O'ReillySGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-7515-0845
Elin OrgEstonian Genome Center, University of Tartu, Tartu, Estonia.
Sandosh PadmanabhanGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
Walter PalmasDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Alison PattieDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands.
Markus PerolaDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Ozren PolasekDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Peter P PramstallerInstitute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Quang Tri NguyenMathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Meixia RenFujian Key Laboratory of Geriatrics, Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
Rainer RettigInstitute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Janina S RiedInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Harriëtte RieseInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Antonietta RobinoInstitute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0001-6993-6884
Daniela RuggieroInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Napoli, Italy.
Yasaman SabaGottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Cinzia F SalaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Veikko SalomaaDepartment of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Antti-Pekka SarinInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Helena SchmidtGottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Nick ShrineDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-3641-4371
David SiscovickThe New York Academy of Medicine, New York, NY, USA.
Albert V SmithFaculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Siim SõberInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-8530-2600
Rossella SoriceInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Napoli, Italy.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, UK.ORCID http://orcid.org/0000-0001-7854-1366
Rona J StrawbridgeCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Johan SundströmDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2247-8454
Morris A SwertzDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-0979-3401
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Alexander TeumerDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-3596-7874
Maciej TomaszewskiDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Michela TragliaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Jaakko TuomilehtoDasman Diabetes Institute, Dasman, Kuwait.
Christophe TzourioUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, CHU Bordeaux, Bordeaux, France.
André G UitterlindenDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Ahmad VaezDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-9048-3795
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Anne-Claire VergnaudDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Germaine C VerwoertDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Veronique VitartMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
Uwe VölkerDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Peter VollenweiderDepartment of Internal Medicine, University Hospital, CHUV, Lausanne, Switzerland.
Dragana VuckovicDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Sarah H WildCentre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ Institute, VU University Medical Center, Amsterdam, the Netherlands.
James F WilsonMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0001-5751-9178
Alan F WrightMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tatijana ZemunikDepartment of Biology, Faculty of Medicine, University of Split, Split, Croatia.ORCID http://orcid.org/0000-0001-8120-2891
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
John R AttiaHunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9800-1308
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
David ConenDivision of Cardiology, University Hospital, Basel, Switzerland.
Francesco CuccaInstitute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Cagliari, Italy.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0002-9405-9550
Joanna M M HowsonMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7618-0050
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Olle MelanderDepartment Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Colin N A PalmerDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-6415-6560
Lorenz RischLabormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Rodney J ScottHunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Peter SeverNational Heart and Lung Institute, Imperial College London, London, UK.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Eleftheria ZegginiWellcome Trust Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4238-659X
Daniel LevyNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-4176-2947
Christopher Newton-ChehProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Morris J BrownWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Adriana M HungTennessee Valley Healthcare System (Nashville VA) & Vanderbilt University, Nashville, TN, USA.
Christopher J O'DonnellVA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4318-6119
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-4275-9328
Michael R BarnesWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9097-7381
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-4951-1867
Paul ElliottDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK. p.elliott@imperial.ac.uk.ORCID http://orcid.org/0000-0002-7511-5684
Mark J CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. m.j.caulfield@qmul.ac.uk.ORCID http://orcid.org/0000-0001-9295-3594
Million Veteran Program

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI PARSONNET, JULIE · 1985 to 2008
$32.4M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Statistical genetics of aging-related genomic and phenotypic changeZIAAG000693 · NIA · NATIONAL INSTITUTE ON AGING · PI DING, JUN · 2011 to 2025
$12.5M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Biotechnology and Biological Sciences Research Council BB/F019394/1BLRD VA I01 BX003360British Heart Foundation FS/12/82/29736British Heart Foundation RG/08/014/24067British Heart Foundation RG/13/13/30194British Heart Foundation RG/15/12/31616British Heart Foundation SP/13/2/30111Cancer Research UK 14136CSRD VA I01 CX000982Medical Research Council G0401527Medical Research Council G0601966Medical Research Council G1000143Medical Research Council G1001799Medical Research Council MC_PC_13040Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/3Medical Research Council MC_UU_12015/4Medical Research Council MC_UU_12015/5Medical Research Council MC_UU_12015/7Medical Research Council MR/K007017/1Medical Research Council MR/L003120/1Medical Research Council MR/L01341X/1Medical Research Council MR/L016311/1Medical Research Council MR/L01632X/1Medical Research Council MR/M004422/1Medical Research Council MR/M016560/1Medical Research Council MR/M501633/1Medical Research Council MR/N003284/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/N015746/1Medical Research Council MR/R023484/1Medical Research Council MR/S003061/1Medical Research Council MR/S003746/1NCI NIH HHS T32 CA160056NCRR NIH HHS M01 RR000070NHGRI NIH HHS U01 HG007417NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL121429NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01 HL137162NICHD NIH HHS K12 HD043483NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK102163NIH HHS S10 OD023680Wellcome Trust
6 · The paper itself

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Indexed as

Quantitative Trait LociAdultAgedAged, 80 and overBlood PressureCardiovascular DiseasesCells, CulturedFemaleGenetic LociGenetic Predisposition to DiseaseGenetics, PopulationGenetic TestingGenome-Wide Association StudyHumansHuman Umbilical Vein Endothelial CellsHypertension

Identifiers

PMID30224653
PMCPMC6284793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.