Evidence map›Paper›PMID 30224643›Full record

ArticleNature genetics2018

Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer.

Giulia Orlando, Philip J Law, Alex J Cornish, Sara E Dobbins, Daniel Chubb, Peter Broderick, Kevin Litchfield, Fadi Hariri, Tomi Pastinen, Cameron S Osborne and 2 more

Abstract read
In one paragraph

Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Giulia OrlandoDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-9663-4611
Alex J CornishDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-3966-3501
Sara E DobbinsDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-5320-3467
Daniel ChubbDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Peter BroderickDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-8348-5829
Kevin LitchfieldDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Fadi HaririMcGill University and Genome Quebec Innovation Centre, Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Tomi PastinenMcGill University and Genome Quebec Innovation Centre, Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Cameron S OsborneDepartment of Medical and Molecular Genetics, King's College London, London, UK.
Jussi TaipaleDivision of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, and Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK. richard.houlston@icr.ac.uk.ORCID http://orcid.org/0000-0002-5268-0242
Institute of Cancer Research · GBChildren's Mercy Hospital · USKing's College London · GBMcGill University and Génome Québec Innovation Centre · CAUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efforts are being directed to systematically analyze the non-coding regions of the genome for cancer-driving mutations

Indexed as

Codon, NonsenseCaco-2 CellsCell Transformation, NeoplasticChromosomes, HumanColorectal NeoplasmsComputational BiologyDatabases, GeneticDNA, NeoplasmGene FrequencyHeLa CellsHep G2 CellsHigh-Throughput Nucleotide SequencingHT29 CellsHumansK562 CellsMCF-7 CellsCodon, NonsenseDNA, Neoplasm

Identifiers

PMID30224643
PMCPMC6380472
OpenAlexW2890879010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.