Evidence map›Paper›PMID 30224532›Full record

ArticleAntimicrobial agents and chemotherapy2018

Synthesis, Biological Evaluation, and Molecular Modeling Studies of Chiral Chloroquine Analogues as Antimalarial Agents.

Srinivasarao Kondaparla, Utsab Debnath, Awakash Soni, Vasantha Rao Dola, Manish Sinha, Kumkum Srivastava, Sunil K Puri, Seturam B Katti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Srinivasarao Kondaparla *Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.
Utsab Debnath *Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.ORCID 0000-0001-9776-2391
Awakash SoniParasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Vasantha Rao DolaMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.
Manish SinhaMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.
Kumkum SrivastavaParasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Sunil K PuriParasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Seturam B KattiMedicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India setu_katti@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a focused exploration, we designed, synthesized, and biologically evaluated chiral conjugated new chloroquine (CQ) analogues with substituted piperazines as antimalarial agents.

Indexed as

AnimalsAntimalarialsChlorocebus aethiopsChloroquineDrug DesignDrug ResistanceErythrocytesHemeHemeproteinsHumansHydrophobic and Hydrophilic InteractionsInhibitory Concentration 50MalariaMiceMolecular Docking SimulationParasitic Sensitivity TestsAntimalarialsChloroquineHemeHemeproteinshemozoinPiperazines3D-QSARCQ-sensitive strain 3D7dockingheme binding assayin vitro assayin vivo assaypiperazines

Identifiers

PMID30224532
PMCPMC6256754

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.