Evidence map›Paper›PMID 30224525›Full record

ArticleAntimicrobial agents and chemotherapy2018

Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers.

Russell J Benefield, E Susan Slechta, Christopher M Gast, Emily S Spivak, Kimberly E Hanson, Donald P Alexander

Open access · bronzeAbstract readClinical StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Clinical Pharmacokinetics of Daptomycin.Clinical pharmacokinetics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Russell J BenefieldUniversity of Utah Health, Department of Pharmacy, Salt Lake City, Utah, USA russell.benefield@hsc.utah.edu.ORCID 0000-0002-3235-6285
E Susan SlechtaARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA.
Christopher M GastBiostatistical consultant, Woodinville, Washington, USA.
Emily S SpivakUniversity of Utah School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, Salt Lake City, Utah, USA.
Kimberly E HansonARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA.
Donald P AlexanderUniversity of Utah Health, Department of Pharmacy, Salt Lake City, Utah, USA.
University of Utah · USARUP Institute for Clinical and Experimental PathologyBiostatistical Consulting (United States) · US

Funding

University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
NCATS NIH HHS UL1 TR001067
6 · The paper itself

Abstract

We evaluated the effects of rifampin coadministration and

Indexed as

Polymorphism, Single NucleotideAdministration, OralAdultAllelesAnti-Bacterial AgentsArea Under CurveATP Binding Cassette Transporter, Subfamily BBiological AvailabilityDaptomycinDrug CombinationsDrug InteractionsFemaleGene ExpressionGenotypeHalf-LifeHealthy VolunteersABCB1 protein, humanAnti-Bacterial AgentsATP Binding Cassette Transporter, Subfamily BDaptomycinDrug CombinationsRifampinABC transportersdaptomycinMDR1p-glycoproteinpharmacogeneticspharmacokineticsrifampin

Identifiers

PMID30224525
PMCPMC6256791
OpenAlexW2890179149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.