Evidence map›Paper›PMID 30224520›Full record

ArticleMolecular and cellular biology2018

Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.

Shota Sasaki, Mizuho Urabe, Tsukasa Maeda, Junko Suzuki, Ryota Irie, Masanori Suzuki, Yasuhiro Tomaru, Masakiyo Sakaguchi, Frank J Gonzalez, Yusuke Inoue

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Epistatic contributions to human traits via transcription factor mechanisms.medRxiv : the preprint server for health sciences · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Functional inhibition of Oct leads to HNF4α upregulation.Experimental and therapeutic medicine · 2021
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Shota SasakiDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Mizuho UrabeDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Tsukasa MaedaDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Junko SuzukiDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Ryota IrieDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Masanori SuzukiRIKEN Omics Science Center, Yokohama, Kanagawa, Japan.
Yasuhiro TomaruRIKEN Omics Science Center, Yokohama, Kanagawa, Japan.
Masakiyo SakaguchiDepartment of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Yusuke InoueDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan yinoue@gunma-u.ac.jp.
Gunma University · JPRIKEN Center for Integrative Medical Sciences · JPNational Cancer Institute · USOkayama University · JP

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
6 · The paper itself

Abstract

Hepatocyte nuclear factor 4α (HNF4α) is a critical factor for hepatocyte differentiation. HNF4α expression is decreased in hepatocellular carcinoma (HCC), which suggests a role in repression of hepatocyte dedifferentiation. In the present study, hepatic expression of HNF4γ was increased in liver-specific

Indexed as

Amino Acid SequenceAnimalsBase SequenceCaco-2 CellsCarcinoma, HepatocellularCell DifferentiationCell LineCell Line, TumorGenetic VariationHCT116 CellsHEK293 CellsHeLa CellsHepatocyte Nuclear Factor 4HepatocytesHep G2 CellsHT29 CellsHepatocyte Nuclear Factor 4HNF4G protein, humanRNA, Messengerhepatocellular carcinomaHNF4γredifferentiationtransactivation

Identifiers

PMID30224520
PMCPMC6275183
OpenAlexW2891053063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.