Evidence map›Paper›PMID 30224484›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA.

Chengming Zhu, Qi Yan, Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng, Shouhong Guang

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  5. Article
  6. Article
  7. The role of m5C, m1A and m7G modifications in tumors of urinary system.Frontiers in cell and developmental biology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. RNA modifications in cancer.British journal of cancer · 2023
    Review
  17. Article
  18. Oligonucleotide Catabolism-Derived Gluconucleosides inJournal of the American Chemical Society · 2023
    Article
  19. Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chengming ZhuHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China.
Qi YanHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China.
Chenchun WengHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China.
Xinhao HouHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China.
Hui MaoHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China.
Dun LiuHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China.
Xuezhu FengHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China; fengxz@ustc.edu.cn sguang@ustc.edu.cn.
Shouhong GuangHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, People's Republic of China; fengxz@ustc.edu.cn sguang@ustc.edu.cn.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified a class of antisense ribosomal siRNAs (risiRNAs) that down-regulate pre-rRNAs through the nuclear RNAi pathway. To further understand the biological roles of risiRNAs, we conducted both forward and reverse genetic screens to search for more suppressor of siRNA (

Indexed as

Gene SilencingMethyltransferasesNuclear ProteinsRNA, RibosomalRNA, Ribosomal, 18SRNA, Small InterferingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsHumansProtein O-MethyltransferaseRNA-Binding ProteinsMethyltransferasesNuclear ProteinsProtein O-MethyltransferaseRNA-Binding ProteinsRNA, RibosomalRNA, Ribosomal, 18SRNA, ribosomal, 26SRNA, Small InterferingRRP8 protein, humanRRP8 protein, S cerevisiaeSaccharomyces cerevisiae Proteins7-methylguanosineN1-methyladenosineNrderisiRNArRNA

Identifiers

PMID30224484
PMCPMC6176571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.