Evidence map›Paper›PMID 30224470›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Regulatory γ1 subunits defy symmetry in functional modulation of BK channels.

Vivian Gonzalez-Perez, Manu Ben Johny, Xiao-Ming Xia, Christopher J Lingle

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Regulatory mechanisms of mitochondrial BKChannels (Austin, Tex.) · 2021
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vivian Gonzalez-PerezDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
Manu Ben JohnyDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Xiao-Ming XiaDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
Christopher J LingleDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110; clingle@morpheus.wustl.edu.ORCID 0000-0002-9916-3795

Funding

SLO family potassium channels: function and physiologyR35GM118114 · NIGMS · WASHINGTON UNIVERSITY · PI LINGLE, CHRISTOPHER J · 2016 to 2025
$6.9M
NIGMS NIH HHS R35 GM118114
6 · The paper itself

Abstract

Structural symmetry is a hallmark of homomeric ion channels. Nonobligatory regulatory proteins can also critically define the precise functional role of such channels. For instance, the pore-forming subunit of the large conductance voltage and calcium-activated potassium (BK, Slo1, or KCa

Indexed as

AnimalsFluorescence Resonance Energy TransferIon Channel GatingLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMiceProtein SubunitsXenopus laevisKcnma1 protein, mouseLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsProtein SubunitsBK channelsFRETK+ channelsregulatory subunitsstoichiometry

Identifiers

PMID30224470
PMCPMC6176617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.