ArticleProceedings of the National Academy of Sciences of the United States of America2018
Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Catecholamines in Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2020Pooled it
- The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Foreign Language Learning in Older Adults Modifies Resting-State Functional Connectivity Between the Subcortical Structures and the Cortex.Aging medicine (Milton (N.S.W)) · 2026Article
- Mesoscale molecular architecture of the human striatum across cell types and lifespan.bioRxiv : the preprint server for biology · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Amyloid burden, brain metabolism, and gray matter volume in SuperAgers.Arquivos de neuro-psiquiatria · 2026Article
- Intrinsic brain functional connectivity mediates the relationship between psychological resilience and cognitive decline in ageing.GeroScience · 2025Article
- Age Differences in Brain Functional Connectivity Underlying Proactive Interference in Working Memory.Human brain mapping · 2025Article
- Cerebellar gray matter atrophy and altered structural covariance networks are associated with cognitive impairment in type 2 diabetes mellitus.Frontiers in neurology · 2025Article
- Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional brain activations correlated with association strength and prediction error during novel symbol-speech sound learning.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Pathological and neurochemical correlates of locus coeruleus functional network activity.Biological psychology · 2024Article
- Long-Term Impact of Diffuse Traumatic Brain Injury on Neuroinflammation and Catecholaminergic Signaling: Potential Relevance for Parkinson's Disease Risk.Molecules (Basel, Switzerland) · 2024Article
- Caudate functional networks influence brain structural changes with aging.Brain communications · 2024Article
- Alteration in temporal-cerebellar effective connectivity can effectively distinguish stable and progressive mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Hippocampal subfield volumes contribute to working memory interference control in aging: Evidence from longitudinal associations over 5 years.Neuroimage. Reports · 2023Article
- Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Dopamine D1-signaling modulates maintenance of functional network segregation in aging.Aging brain · 2023Article
- Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury.Annals of neurology · 2022Article
- Effects of exploring a novel environment on memory across the lifespan.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Age-related changes in striatal function are potentially important for predicting declining memory performance over the adult life span. Here, we used fMRI to measure functional connectivity of caudate subfields with large-scale association networks and positron emission tomography to measure striatal dopamine transporter (DAT) density in 51 older adults (age 65-86 years) who received annual cognitive testing for up to 7 years (mean = 5.59, range 2-7 years). Analyses showed that cortical-caudate functional connectivity was less differentiated in older compared with younger adults (
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