ArticleProceedings of the National Academy of Sciences of the United States of America2018
Leak potassium channels regulate sleep duration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary Supplement Interventions and Sleep Quality Improvement: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- Resting-Potential-Inspired Solid-State Iontronic Osmotic Power Source Enabled by Polarized MXene.Nano-micro letters · 2026Article
- Biological Mechanisms of Sleep/Wake-Related Function.Biological psychiatry · 2025Review
- Structure of the human KNature structural & molecular biology · 2025Article
- A unified framework to model synaptic dynamics during the sleep-wake cycle.PLoS biology · 2025Article
- Article
- Studying sleep orthologs in Epsilonproteobacteria through an evolutionary lens: investigating sleep mysteries through phylogenomics.World journal of microbiology & biotechnology · 2025Article
- Article
- Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles.Nature · 2024Article
- Development of covalent chemogenetic KCell chemical biology · 2024Article
- Structure of the human KbioRxiv : the preprint server for biology · 2024Article
- Deciphering Post-Stroke Sleep Disorders: Unveiling Neurological Mechanisms in the Realm of Brain Science.Brain sciences · 2024Review
- Diverse roles of pontine NPS-expressing neurons in sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Development of covalent chemogenetic KbioRxiv : the preprint server for biology · 2023Article
- Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.Nature communications · 2023Article
- Information maximization explains state-dependent synaptic plasticity and memory reorganization during non-rapid eye movement sleep.PNAS nexus · 2023Article
- Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling.Molecular psychiatry · 2022Article
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- Article
- Towards organism-level systems biology by next-generation genetics and whole-organ cell profiling.Biophysical reviews · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A primary goal of sleep research is to understand the molecular basis of sleep. Although some sleep/wake-promoting circuits and secreted substances have been identified, the detailed molecular mechanisms underlying the regulation of sleep duration have been elusive. Here, to address these mechanisms, we developed a simple computational model of a cortical neuron with five channels and a pump, which recapitulates the cortical electrophysiological characteristics of slow-wave sleep (SWS) and wakefulness. Comprehensive bifurcation and detailed mathematical analyses predicted that leak K
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