Evidence map›Paper›PMID 30224460›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.

Feng Zhang, Yaqing Wang, Tao Wang, Li Yao, Sin Man Lam, Xiahe Huang, Junwan Fan, Qin Wang, Liang Liu, Yisheng Jiang and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. TAPT1 interacts with SUCO to maintain the homeostasis of newly synthesized proteins and brain development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  10. Rat and fish peripheral blood leukocytes respond distinctively toFrontiers in cellular and infection microbiology · 2022
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  14. Deletion ofFrontiers in cell and developmental biology · 2020
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  17. The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer.International journal of biological sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Feng ZhangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.ORCID 0000-0003-2887-8184
Yaqing WangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Tao WangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Li YaoState Key Laboratory of Cognitive Neuroscience & Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875 Beijing, China.
Sin Man LamState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Xiahe HuangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Junwan FanState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Qin WangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Liang LiuState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Yisheng JiangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Hongsheng ZhangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Lei ShiState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Mei YuState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Guanghou ShuiState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Yingchun WangState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Fei GaoState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
Xiaohui ZhangState Key Laboratory of Cognitive Neuroscience & Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875 Beijing, China.
Zhiheng XuState Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China; zhxu@genetics.ac.cn.ORCID 0000-0002-4809-2851
Chinese Academy of Sciences · CNBeijing Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Normal neural development is essential for the formation of neuronal networks and brain function. Cutaneous T cell lymphoma-associated antigen 5 (cTAGE5)/meningioma expressed antigen 6 (MEA6) plays a critical role in the secretion of proteins. However, its roles in the transport of nonsecretory cellular components and in brain development remain unknown. Here, we show that cTAGE5/MEA6 is important for brain development and function. Conditional knockout of

Indexed as

AnimalsAntigens, NeoplasmAstrocytesBiological Transport, ActiveBrainCoat Protein Complex IMiceMice, KnockoutMutationNeoplasm ProteinsNeuronsAntigens, NeoplasmCoat Protein Complex ICTAGE5 protein, mouseNeoplasm Proteinsbrain developmentCOPIIcTAGE5MEA6vesicle trafficking

Identifiers

PMID30224460
PMCPMC6176567
OpenAlexW2889808316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.