ArticleProceedings of the National Academy of Sciences of the United States of America2018
Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
37 citing papers in PubMed, 63 citations in OpenAlex.
- Kinetically Divergent Dimanganese-Tyrosyl Radical Cofactor Assembly in Listeria monocytogenes Class I Ribonucleotide Reductase.Biochemistry · 2026Article
- Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Ribonucleotide reductases recapitulate biogeographic patterns within virioplankton according to ocean biogeochemistry.bioRxiv : the preprint server for biology · 2026Article
- A Structurally Divergent Class Ia Ribonucleotide Reductase from a Tick-Borne Pathogen.Biochemistry · 2025Article
- Design and characterization of a tunable open TEJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- The iron metalloproteome of Pseudomonas aeruginosa under oxic and anoxic conditions.Metallomics : integrated biometal science · 2025Article
- Characterization of a second class Ie ribonucleotide reductase.Communications biology · 2025Article
- Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking.Chemical reviews · 2024Review
- Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature's Known Radical Chemistry.Journal of the American Chemical Society · 2024Article
- Conformational control over proton-coupled electron transfer in metalloenzymes.Nature reviews. Chemistry · 2024Review
- Protein engineering a PhotoRNR chimera based on a unifying evolutionary apparatus among the natural classes of ribonucleotide reductases.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A novel alkane monooxygenase evolved from a broken piece of ribonucleotide reductase in Geobacillus kaustophilus HTA426 isolated from Mariana Trench.Extremophiles : life under extreme conditions · 2024Article
- Structure of a ribonucleotide reductase R2 protein radical.Science (New York, N.Y.) · 2023Article
- Collagen breaks at weak sacrificial bonds taming its mechanoradicals.Nature communications · 2023Article
- Characterisation of aneLife · 2023Article
- Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023Review
- Analysis of insertions and extensions in the functional evolution of the ribonucleotide reductase family.Protein science : a publication of the Protein Society · 2022Article
- Article
- Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade.eLife · 2022Article
- Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present.Biomolecules · 2022Review
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Authors and funding
18 authors at 3 institutions in 1 country.
Elizabeth J BlaesiDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.
Gavin M PalowitchDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.
Kai HuDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.
Amelia J KimDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.
Hannah R RoseDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.
Rahul AlapatiDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.
Marshall G LougeeDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104.
Hee Jong KimBiochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Alexander T TaguchiDepartment of Chemistry, Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Kong Ooi TanDepartment of Chemistry, Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Tatiana N LaremoreHuck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802.
Robert G GriffinDepartment of Chemistry, Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; ckrebs@psu.edu megamatt@sas.upenn.edu aus40@psu.edu jmb21@psu.edu bda3@psu.edu akb20@psu.edu.ORCID 0000-0002-3302-7053
Megan L MatthewsDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104; ckrebs@psu.edu megamatt@sas.upenn.edu aus40@psu.edu jmb21@psu.edu bda3@psu.edu akb20@psu.edu.
Alexey SilakovDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; ckrebs@psu.edu megamatt@sas.upenn.edu aus40@psu.edu jmb21@psu.edu bda3@psu.edu akb20@psu.edu.
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; ckrebs@psu.edu megamatt@sas.upenn.edu aus40@psu.edu jmb21@psu.edu bda3@psu.edu akb20@psu.edu.
Benjamin D AllenDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802; ckrebs@psu.edu megamatt@sas.upenn.edu aus40@psu.edu jmb21@psu.edu bda3@psu.edu akb20@psu.edu.
Amie K BoalDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; ckrebs@psu.edu megamatt@sas.upenn.edu aus40@psu.edu jmb21@psu.edu bda3@psu.edu akb20@psu.edu.
Pennsylvania State University · USMassachusetts Institute of Technology · USUniversity of Pennsylvania · US
Funding
Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0MHigh-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0MMechanisms of Radical Translocation in Class I Ribonucleotide ReductasesF32GM116353 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BLAESI, ELIZABETH J · 2015 to 2017
$160kNIGMS NIH HHS F32 GM116353NIGMS NIH HHS R35 GM119707NIH HHS S10 OD012289
Abstract
All cells obtain 2'-deoxyribonucleotides for DNA synthesis through the activity of a ribonucleotide reductase (RNR). The class I RNRs found in humans and pathogenic bacteria differ in (
Indexed as
DihydroxyphenylalanineEscherichia coliEscherichia coli ProteinsFree RadicalsRibonucleotide ReductasesTyrosineDihydroxyphenylalanineEscherichia coli ProteinsFree RadicalsRibonucleotide ReductasesTyrosineDNA biosynthesisDOPAsemiquinone
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