Trial reportProceedings of the National Academy of Sciences of the United States of America2018
Hippocampal CA1 gamma power predicts the precision of spatial memory judgments.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Neuroprotective Effects of Ficus deltoidea in Alzheimer's Disease-Like Rat Model: Insights from Behavior, Histology, and Amyloid Pathology.Molecular neurobiology · 2026Article
- Prosapip1 (encoded by theeLife · 2025Article
- Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer's and Parkinson's disease.Scientific reports · 2025Article
- Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval.Nature communications · 2023Article
- Effects of high-frequency transcranial magnetic stimulation on theta-gamma oscillations and coupling in the prefrontal cortex of rats during working memory task.Medical & biological engineering & computing · 2023Article
- Differential effects of aging on hippocampal ultrastructure in male vs. female rats.Biogerontology · 2023Article
- Extended trajectory of spatial memory errors in typical and atypical development: The role of binding and precision.Hippocampus · 2023Article
- Dysfunction of NRG1/ErbB4 Signaling in the Hippocampus Might Mediate Long-term Memory Decline After Systemic Inflammation.Molecular neurobiology · 2023Article
- Physical but not virtual presence of others potentiates implicit and explicit learning.Scientific reports · 2022Article
- Replicable patterns of causal information flow between hippocampus and prefrontal cortex during spatial navigation and spatial-verbal memory formation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Structure-Function Dissociations of Human Hippocampal Subfield Stiffness and Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Beyond rates: time-varying dynamics of high frequency oscillations as a biomarker of the seizure onset zone.Journal of neural engineering · 2022Article
- Perspective taking and systematic biases in object location memory.Attention, perception & psychophysics · 2021Article
- Memory precision of object-location binding is unimpaired inBrain communications · 2021Article
- Insights into human cognition from intracranial EEG: A review of audition, memory, internal cognition, and causality.Journal of neural engineering · 2020Review
- Venlafaxine Stimulates an MMP-9-Dependent Increase in Excitatory/Inhibitory Balance in a Stress Model of Depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.Aging cell · 2020Article
- The dynamic properties of a brain network during working memory based on the algorithm of cross-frequency coupling.Cognitive neurodynamics · 2020Article
- Pattern Separation and Source Memory Engage Distinct Hippocampal and Neocortical Regions during Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The hippocampus plays a critical role in spatial memory. However, the exact neural mechanisms underlying high-fidelity spatial memory representations are unknown. We report findings from presurgical epilepsy patients with bilateral hippocampal depth electrodes performing an object-location memory task that provided a broad range of spatial memory precision. During encoding, patients were shown a series of objects along the circumference of an invisible circle. At test, the same objects were shown at the top of the circle (0°), and patients used a dial to move the object to its location shown during encoding. Angular error between the correct location and the indicated location was recorded as a continuous measure of performance. By registering pre- and postimplantation MRI scans, we were able to localize the electrodes to specific hippocampal subfields. We found a correlation between increased gamma power, thought to reflect local excitatory activity, and the precision of spatial memory retrieval in hippocampal CA1 electrodes. Additionally, we found a similar relationship between gamma power and memory precision in the dorsolateral prefrontal cortex and a directional relationship between activity in this region and in the CA1, suggesting that the dorsolateral prefrontal cortex is involved in postretrieval processing. These results indicate that local processing in hippocampal CA1 and dorsolateral prefrontal cortex supports high-fidelity spatial memory representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.