Evidence map›Paper›PMID 30224430›Full record

ArticleMolecular cancer therapeutics2018

Targeting Peroxisome Proliferator-Activated Receptor γ to Increase Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells.

Ping Fan, Balkees Abderrahman, Tina S Chai, Smitha Yerrum, V Craig Jordan

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  10. Article
  11. Review
  12. Article
  13. First Evidence for a Role of Siglec-8 in Breast Cancer.International journal of molecular sciences · 2021
    Article
  14. Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, βInternational journal of molecular sciences · 2021
    Article
  15. Article
  16. Targets for protection and mitigation of radiation injury.Cellular and molecular life sciences : CMLS · 2020
    Review
  17. Article
  18. Article
  19. New insights into acquired endocrine resistance of breast cancer.Cancer drug resistance (Alhambra, Calif.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ping FanDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Balkees AbderrahmanDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Tina S ChaiDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Smitha YerrumDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
V Craig JordanDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. VCJordan@mdanderson.org.
University of Virginia · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Intramural NIH HHS Z99 RG999999NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) is an important transcription factor that modulates lipid metabolism and inflammation. However, it remains unclear whether PPARγ is involved in modulation of estrogen (E

Indexed as

ApoptosisMolecular Targeted TherapyBreast NeoplasmsCell Line, TumorCell ProliferationDNAEstrogensFemaleHumansInflammationNF-kappa BOxidative StressPPAR gammaProtein BindingSignal TransductionTumor Necrosis Factor-alphaDNAEstrogensNF-kappa BPPAR gammaTumor Necrosis Factor-alpha

Identifiers

PMID30224430
PMCPMC6279501
OpenAlexW2892284383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.