Evidence map›Paper›PMID 30224381›Full record

ArticleEMBO molecular medicine2018

Anett Pfeiffer, Frederic B Thalheimer, Sylvia Hartmann, Annika M Frank, Ruben R Bender, Simon Danisch, Caroline Costa, Winfried S Wels, Ute Modlich, Renata Stripecke and 2 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 180 citations in OpenAlex.

  1. Genes & diseases · 2027
    Review
  2. Article
  3. Review
  4. Review
  5. Biomaterial-EnabledCell biomaterials · 2026
    Article
  6. Nanomaterials Drive In Vivo CAR Immune Cells Engineering.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Beyond autologousMolecular therapy. Oncology · 2026
    Review
  16. Article
  17. In Vivo CAR-T Therapies-A New Era of Programmable Immunity.International journal of molecular sciences · 2026
    Review
  18. In vivo chimeric antigen receptor (CAR)-T cell therapy.Nature reviews. Drug discovery · 2026
    Review
  19. FromImmune network · 2026
    Review
  20. Review

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Anett PfeifferMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Frederic B ThalheimerMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Sylvia HartmannDr. Senckenberg Institute of Pathology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Annika M FrankMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Ruben R BenderMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Simon DanischDepartment of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH and German Centre for Infection Research (DZIF), partner site Hannover, Hannover, Germany.
Caroline CostaCIRI - International Center for Infectiology Research, Team EVIR, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, University of Lyon, Lyon, France.
Winfried S WelsInstitute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
Ute ModlichDivision of Veterinary Medicine, Research Group for Gene Modification in Stem Cells, Paul-Ehrlich-Institut, Langen, Germany.
Renata StripeckeDepartment of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH and German Centre for Infection Research (DZIF), partner site Hannover, Hannover, Germany.
Els VerhoeyenCIRI - International Center for Infectiology Research, Team EVIR, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, University of Lyon, Lyon, France.
Christian J BuchholzMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany christian.buchholz@pei.de.ORCID 0000-0002-9837-7345
Paul Ehrlich Institut · DEGerman Cancer Research Center · DEUniversité Claude Bernard Lyon 1 · FRGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T cells brought substantial benefit to patients with B-cell malignancies. Notwithstanding, CAR T-cell manufacturing requires complex procedures impeding the broad supply chain. Here, we provide evidence that human CD19-CAR T cells can be generated directly

Indexed as

Lymphocyte DepletionAnimalsAntigens, CD19B-LymphocytesCytokinesGraft vs Host DiseaseHEK293 CellsHumansLeukocytes, MononuclearMiceReceptors, Chimeric AntigenSyndromeT-LymphocytesAntigens, CD19CytokinesReceptors, Chimeric Antigencytokine release syndromegene deliveryhumanized mouseT‐cell targeting

Identifiers

PMID30224381
PMCPMC6220327
OpenAlexW2889863283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.