ArticleThe Journal of biological chemistry2018
Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- MK4 Repositioning for IAHSP: OvercomingACS chemical neuroscience · 2026Article
- Molecular Insights into IAHSP: Influence of the R1611W Mutation on the VPS9 Domain of Alsin.ACS omega · 2025Article
- Review
- Article
- lncRNA Sequencing Reveals Neurodegeneration-associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists In Motor Neurons.Research square · 2023Article
- Genetic and clinical features of pediatric-onset hereditary spastic paraplegia: a single-center study in Japan.Frontiers in neurology · 2023Article
- Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies.Molecules (Basel, Switzerland) · 2022Article
- Multiple roles for the cytoskeleton in ALS.Experimental neurology · 2022Review
- Modelling amyotrophic lateral sclerosis in rodents.Nature reviews. Neuroscience · 2022Review
- ALS2-related disorders in Spanish children: a severely affected case of infantile ascending spastic paraplegia due to homozygous R704X mutation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- 2-Year-Old and 3-Year-Old Italian ALS Patients with NovelMetabolites · 2022Article
- Review
- In silico investigation of Alsin RLD conformational dynamics and phosphoinositides binding mechanism.PloS one · 2022Article
- Whole Genome Sequencing Analysis to Identify Candidate Genes Associated With the rib eye Muscle Area in Hu Sheep.Frontiers in genetics · 2022Article
- ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival.The Journal of cell biology · 2021Article
- Prediction of Protein-Protein Interactions Between Alsin DH/PH and Rac1 and Resulting Protein Dynamics.Frontiers in molecular neuroscience · 2021Article
- The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells.Scientific reports · 2020Article
- Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs.Neurobiology of disease · 2019Review
- The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.International journal of molecular sciences · 2019Article
- A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS.Frontiers in neurology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial amyotrophic lateral sclerosis type 2 (ALS2) is a juvenile autosomal recessive motor neuron disease caused by the mutations in the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.