Evidence map›Paper›PMID 30224340›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Tracking Cell Transplants in Femoral Osteonecrosis with Magnetic Resonance Imaging: A Proof-of-Concept Study in Patients.

Ashok J Theruvath, Hossein Nejadnik, Anne M Muehe, Felix Gassert, Norman J Lacayo, Stuart B Goodman, Heike E Daldrup-Link

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02893293 (Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02893293 phase4completednot on this map

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI

TypeinterventionalSponsorStanford UniversityRan2015 to 2023Enrolled14ConditionsOsteonecrosisArmsFerumoxytol-enhanced magnetic resonance imaging, Magentic Resonance Imaging
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ashok J TheruvathDepartment of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
Hossein NejadnikDepartment of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
Anne M MueheDepartment of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.ORCID 0000-0003-3893-5242
Felix GassertDepartment of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
Norman J LacayoDepartment of Pediatrics, Pediatric Hematology/Oncology, Lucile Packard Children's Hospital and Stanford Cancer Center, Stanford University, Stanford, California.
Stuart B GoodmanDepartment of Orthopaedic Surgery and Bioengineering, Stanford Hospital, Stanford University, Stanford, California.ORCID 0000-0002-1919-3717
Heike E Daldrup-LinkDepartment of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California. heiked@stanford.edu.ORCID 0000-0002-4929-819X
Lucile Packard Children's Hospital · USStanford Health Care · US

Funding

Monitoring of Stem Cell Engraftment in Arthritic Joints with MR ImagingR01AR054458 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DALDRUP-LINK, HEIKE ELIZABETH · 2008 to 2021
$6.7M
Personalized Whole Body Staging for Children with Cancer: A Solution to the Conundrum of Long-Term Side Effects from CT and PET/CT ScansR01HD081123 · NICHD · STANFORD UNIVERSITY · PI DALDRUP-LINK, HEIKE ELIZABETH · 2015 to 2019
$2.5M
NIAMS NIH HHS R01 AR054458NICHD NIH HHS R01 HD081123
6 · The paper itself

Abstract

purposeOsteonecrosis is a devastating complication of high-dose corticosteroid therapy in patients with cancer. Core decompression for prevention of bone collapse has been recently combined with the delivery of autologous concentrated bone marrow aspirates. The purpose of our study was to develop an imaging test for the detection of transplanted bone marrow cells in osteonecrosis lesions. EXPERIMENTAL

designIn a prospective proof-of-concept clinical trial (NCT02893293), we performed serial MRI studies of nine hip joints of 7 patients with osteonecrosis before and after core decompression. Twenty-four to 48 hours prior to the surgery, we injected ferumoxytol nanoparticles intravenously to label cells in normal bone marrow with iron oxides. During the surgery, iron-labeled bone marrow cells were aspirated from the iliac crest, concentrated, and then injected into the decompression track. Following surgery, patients received follow-up MRI up to 6 months after bone marrow cell transplantation.

resultsIron-labeled cells could be detected in the access canal by a dark (negative) signal on T2-weighted MR images. T2* relaxation times of iron-labeled cell transplants were significantly lower compared with unlabeled cell transplants of control patients who were not injected with ferumoxytol (

conclusionsThis immediately clinically applicable imaging test could become a powerful new tool to monitor the effect of therapeutic cells on bone repair outcomes after corticosteroid-induced osteonecrosis.

Indexed as

Bone Marrow TransplantationCell TrackingMagnetic Resonance ImagingAdolescentAdultBone RegenerationFemaleFemur Head NecrosisFerrosoferric OxideHumansMagnetite NanoparticlesMaleNeoplasmsProof of Concept StudyStaining and LabelingTreatment OutcomeFerrosoferric OxideMagnetite Nanoparticles

Identifiers

PMID30224340
PMCPMC6295241
OpenAlexW2891641041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.