Evidence map›Paper›PMID 30224336›Full record

ArticleG3 (Bethesda, Md.)2018

An Efficient Genome Editing Strategy To Generate Putative Null Mutants in

Han Wang, Heenam Park, Jonathan Liu, Paul W Sternberg

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
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  10. AbioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. The extracellular matrix genebioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. TAG-IN, a swappable strategy for endogenous gene tagging inbioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Active maintenance of meiosis-specific chromosome structures inbioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Han WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 han.wang@caltech.edu pws@caltech.edu.ORCID 0000-0002-1933-5762
Heenam ParkDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0001-7911-5828
Jonathan LiuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-5761-8704
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 han.wang@caltech.edu pws@caltech.edu.ORCID 0000-0002-7699-0173
California Institute of Technology · US

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Enhancing the C. elegans animal resource through genome editingR24OD023041 · OD · UNIVERSITY OF MINNESOTA · PI ROUGVIE, ANN E., STERNBERG, PAUL WARREN · 2017 to 2024
$5.1M
Mechanisms of Sleep Regulation and Function in C. elegansK99GM126137 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, HAN · 2017 to 2018
$177k
NIGMS NIH HHS K99 GM126137NIGMS NIH HHS T32 GM007616NIH HHS P40 OD010440NIH HHS R24 OD023041
6 · The paper itself

Abstract

Null mutants are essential for analyzing gene function. Here, we describe a simple and efficient method to generate

Indexed as

CRISPR-Cas SystemsGene EditingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsMutationCaenorhabditis elegans ProteinsC. elegansCRISPR/Cas9genome editingnull alleleSTOP-IN

Identifiers

PMID30224336
PMCPMC6222585
OpenAlexW2886062861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.