Evidence map›Paper›PMID 30224066›Full record

ArticleBiochemical and biophysical research communications2018

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.

Cuiwen He, Xuchen Hu, Thomas A Weston, Rachel S Jung, Patrick Heizer, Yiping Tu, Rochelle Ellison, Ken Matsumoto, Holger Gerhardt, Peter Tontonoz and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Targeting the vasculature in cardiometabolic disease.The Journal of clinical investigation · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Biological explorations with nanoscale secondary ion mass spectrometry.Journal of analytical atomic spectrometry · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Cuiwen HeDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Xuchen HuDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Thomas A WestonDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Rachel S JungDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Patrick HeizerDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Yiping TuDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Rochelle EllisonDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA.
Ken MatsumotoVIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.
Holger GerhardtVIB Center for Cancer Biology, KU Leuven, Leuven, Belgium; Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Peter TontonozDepartments of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Loren G FongDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address: lfong@mednet.ucla.edu.
Stephen G YoungDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA; Departments of Human Genetics, University of California, Los Angeles, CA, 90095, USA. Electronic address: sgyoung@mednet.ucla.edu.
Haibo JiangDepartments of Medicine, University of California, Los Angeles, CA, 90095, USA; School of Molecular Sciences and Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth, 6009, Australia. Electronic address: haibo.jiang@uwa.edu.au.
University of California, Los Angeles · USVIB-KU Leuven Center for Cancer Biology · BE

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2008 to 2018
$23.3M
Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2019 to 2023
$11.7M
Refining Physiologic Mechanisms for Intravascular Triglyceride MetabolismR01HL087228 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEIGNEUX, ANNE, FONG, LOREN GI · 2007 to 2024
$7.8M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Investigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1M
Defining mechanisms for lipid transport across capillary endothelial cellsR01HL125335 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2015 to 2017
$1.2M
Investigation of lipid transport using NanoSIMS and backscattered electron imagingF32HL132471 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, CUIWEN · 2016 to 2018
$168k
NHLBI NIH HHS F32 HL132471NHLBI NIH HHS P01 HL090553NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R01 HL087228NHLBI NIH HHS R01 HL125335NHLBI NIH HHS R35 HL139725NHLBI NIH HHS T32 HL069766
6 · The paper itself

Abstract

Heterogeneity in the metabolic properties of adipocytes in white adipose tissue has been well documented. We sought to investigate metabolic heterogeneity in adipocytes of brown adipose tissue (BAT), focusing on heterogeneity in nutrient uptake. To explore the possibility of metabolic heterogeneity in brown adipocytes, we used nanoscale secondary ion mass spectrometry (NanoSIMS) to quantify uptake of lipids in adipocytes interscapular BAT and perivascular adipose tissue (PVAT) after an intravenous injection of triglyceride-rich lipoproteins (TRLs) containing [

Indexed as

Adipocytes, BrownAnimalsCarbon IsotopesFatty AcidsGlucoseLipidsLipoproteinsMice, Inbred C57BLMice, Mutant StrainsNutrientsReceptors, LipoproteinSpectrometry, Mass, Secondary IonCarbon IsotopesFatty AcidsGlucoseGPI-HBP1 protein, mouseLipidsLipoproteinsNutrientsReceptors, LipoproteinBrown adipose tissueFatty acidsNanoSIMS imagingNutrient uptakeWhite adipose tissue

Identifiers

PMID30224066
PMCPMC6476570
OpenAlexW2892344318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.