Evidence map›Paper›PMID 30224027›Full record

ArticleJournal of critical care2018

Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness.

Jessica A Palakshappa, John P Reilly, William D Schweickert, Brian J Anderson, Viviane Khoury, Michael G Shashaty, David Fitzgerald, Caitlin Forker, Kelly Butler, Caroline A Ittner and 5 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05055440 (Evaluation of Peripheral Muscle With Ultrassonografic of Critical Patients With Covid-19), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05055440 completednot on this mapstarted 2021, after this paper: background citation

Evaluation of Peripheral Muscle With Ultrassonografic of Critical Patients With Covid-19

TypeobservationalSponsorUniversity of PernambucoRan2021 to 2022Enrolled30ConditionsCOVID-19 Respiratory Infection
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jessica A PalakshappaDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA; Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest Baptist Health, Winston-Salem, NC 27157, USA. Electronic address: jpalaksh@wakehealth.edu.
John P ReillyDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
William D SchweickertDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Brian J AndersonDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Viviane KhouryDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael G ShashatyDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104, PA, USA.
David FitzgeraldDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Caitlin ForkerDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kelly ButlerDepartment of Occupational and Physical Therapy, Good Shepherd Penn Partners, Philadelphia, PA 19104, USA.
Caroline A IttnerDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rui FengCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104, PA, USA.
D Clark FilesSection of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest Baptist Health, Winston-Salem, NC 27157, USA.
Michael P BonkDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jason D ChristieDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Nuala J MeyerDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · USAtrium Health Wake Forest Baptist · USGood Shepherd Penn Partners · US

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
TRAINING IN PULMONARY IMMUNOLOGYT32HL007586 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 1985 to 2025
$8.8M
Targeting Angiopoietin-2 in ARDSR01HL137006 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2017 to 2021
$2.5M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
Genetic Variation in the ANGPT-TIE Pathway and Risk for Acute Lung InjuryK23HL102254 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2010 to 2014
$685k
Neuron Specific Enolase and Outcomes in Severe SepsisF32GM116637 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ANDERSON, BRIAN J. · 2015 to 2015
$64k
NHLBI NIH HHS K23 HL102254NHLBI NIH HHS K24 HL115354NHLBI NIH HHS R01 HL137006NHLBI NIH HHS T32 HL007586NHLBI NIH HHS T32 HL007891NIGMS NIH HHS F32 GM116637
6 · The paper itself

Abstract

purposeThe objective of this study is to describe the relationship between two quantitative muscle ultrasound measures, the rectus femoris cross-sectional area (RF-CSA) and quadriceps muscle thickness, with volitional measures of strength and function in critically ill patients with sepsis. MATERIALS AND

methodsWe performed a prospective study of patients admitted to a medical ICU with sepsis and shock or respiratory failure. We examined the association of two ultrasound measurements - the RF-CSA and quadriceps muscle thickness - with strength and function at day 7. Strength was determined using the Medical Research Council Score and function using Physical Function in the ICU Test, scored.

resultsTwenty-nine patients were enrolled; 19 patients had outcome testing performed. Over 7days, RF-CSA and thickness decreased by an average of 23.2% and 17.9%, respectively. The rate of change per day of RF-CSA displayed a moderate correlation with strength (ρ 0.51, p-value 0.03) on day 7. Baseline and day 7 RF-CSA did not show a significant correlation with either outcome. Quadriceps muscle thickness did not significantly correlate with either outcome.

conclusionsMuscle atrophy as detected by the rate of change in RF-CSA moderately correlated with strength one week after sepsis admission.

Indexed as

UltrasonographyAdultAgedCritical CareCritical IllnessCross-Sectional StudiesFemaleHumansMaleMiddle AgedMuscular AtrophyProspective StudiesQuadriceps MuscleSepsisShock, SepticICU acquired weaknessMuscle weaknessQuadriceps muscleUltrasonography

Identifiers

PMID30224027
PMCPMC6146408
OpenAlexW2892033790

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.