Observational studyArthritis research & therapy2018
Monosodium urate burden assessed with dual-energy computed tomography predicts the risk of flares in gout: a 12-month observational study : MSU burden and risk of gout flare.
Observational study in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05698680 (Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care
Who cites it
26 citing papers in PubMed.
- Baseline Dual-Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate-Lowering Therapy.Arthritis care & research · 2024Trial
- Combination of dual-energy CT findings and clinical features predicts risk of frequent flares of gout.European radiology · 2026Article
- Gout Inflammation Time Programming: Molecular Clock from Crystal Triggering to Tissue Remodeling.International journal of molecular sciences · 2026Review
- Knowledge, attitudes, and practices regarding gout management among patients in Xiamen, China: a cross-sectional study.Frontiers in public health · 2026Article
- The comprehensive role of dual-energy CT in gout as an advanced diagnostic innovation.Skeletal radiology · 2025Review
- Gout and NLRP3 Inflammasome Biology.Arthritis & rheumatology (Hoboken, N.J.) · 2025Review
- Advanced imaging techniques in crystal arthritis.Therapeutic advances in musculoskeletal disease · 2025Review
- Imaging of gout: an atlas.Rheumatology advances in practice · 2025Review
- Dual-energy computed tomography-based radiomics for differentiating patients with and without gout flares.Clinical rheumatology · 2024Article
- An observational study of ultrasound semiquantitative scoring for predicting the risk of gout flare.Zeitschrift fur Rheumatologie · 2024Observational
- The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout.Therapeutic advances in musculoskeletal disease · 2024Article
- Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential.Journal of inflammation research · 2024Review
- Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout.RMD open · 2023Article
- Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases.Biomolecules · 2023Review
- Impact of Dual-Energy Computed Tomography (DECT) Postprocessing Protocols on Detection of Monosodium Urate (MSU) Deposits in Foot Tendons of Cadavers.Diagnostics (Basel, Switzerland) · 2023Article
- Prevalence of Monosodium Urate (MSU) Deposits in Cadavers Detected by Dual-Energy Computed Tomography (DECT).Diagnostics (Basel, Switzerland) · 2022Article
- Two-year reduction of dual-energy CT urate depositions during a treat-to-target strategy in gout in the NOR-Gout longitudinal study.Rheumatology (Oxford, England) · 2022Article
- Association of urate deposition shown by ultrasound and frequent gout attacks.Zeitschrift fur Rheumatologie · 2021Article
- What Has Dual Energy CT Taught Us About Gout?Current rheumatology reports · 2021Review
- Sonographic estimation of monosodium urate burden predicts the fulfillment of the 2016 remission criteria for gout: a 12-month study.Arthritis research & therapy · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPredicting the risk of flares in patients with gout is a challenge and the link between urate burden and the risk of gout flare is unclear. The objective of this study was to determine if the extent of monosodium urate (MSU) burden measured with dual-energy computed tomography (DECT) and ultrasonography (US) is predictive of the risk of gout flares.
methodsThis prospective observational study recruited patients with gout to undergo MSU burden assessment with DECT (volume of deposits) and US (double contour sign) scans of the knees and feet. Patients attended follow-up visits at 3, 6 and 12 months. Patients having presented with at least one flare at 6 months were compared to those who did not flare. Odds ratios (ORs) (95% confidence interval) for the risk of flare were calculated.
resultsOverall, 64/78 patients included attended at least one follow-up visit. In bivariate analysis, the number of joints with the double contour sign was not associated with the risk of flare (p = 0.67). Multivariate analysis retained a unique variable: DECT MSU volume of the feet. For each 1 cm
conclusionsThis is the first study showing that the extent of MSU burden measured with DECT but not US is predictive of the risk of flares.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.