Evidence map›Paper›PMID 30223738›Full record

ReviewNeurorehabilitation and neural repair2018

Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration.

Liming Qing, Huanwen Chen, Juyu Tang, Xiaofeng Jia

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurorehabilitation and neural repair, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 3 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 3 syntheses or guidelines pooled it, 178 citations in OpenAlex.

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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Liming Qing1 Xiangya Hospital of Central South University, Changsha, Hunan, China.
Huanwen Chen2 University of Maryland School of Medicine, Baltimore, MD, USA.
Juyu Tang1 Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiaofeng Jia2 University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1445-8525
University of Maryland, Baltimore · USCentral South University · CN

Funding

Brain Monitoring and Therapeutic Hypothermia after Cardiac ArrestR01HL118084 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JIA, XIAOFENG · 2013 to 2018
$1.9M
Brain Recovery after Cardiac Arrest with Metabolic Glycoengineered Stem CellsR01NS110387 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JIA, XIAOFENG · 2018 to 2022
$1.7M
NHLBI NIH HHS R01 HL118084NINDS NIH HHS R01 NS110387
6 · The paper itself

Abstract

Peripheral nerve injury is a major clinical problem and often results in a poor functional recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal. In the nervous system, exosomes, which are nanosized extracellular vesicles, play a critical role in mediating intercellular communication. More specifically, microRNA carried by exosomes are involved in various key processes such as nerve and vascular regeneration, and exosomes originating from Schwann cells, macrophages, and mesenchymal stem cells can promote peripheral nerve regeneration. In this review, the current knowledge of exosomes' and their miRNA cargo's role in peripheral nerve regeneration are summarized. The possible future roles of exosomes in therapy and the potential for microRNA-containing exosomes to treat peripheral nerve injuries are also discussed.

Indexed as

AnimalsExosomesHumansMicroRNAsNerve RegenerationPeripheral Nerve InjuriesPeripheral NervesMicroRNAsexosomesmicroRNAnerve regenerationperipheral nerve injury

Identifiers

PMID30223738
PMCPMC6146407
OpenAlexW2889573274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.