Evidence map›Paper›PMID 30223539›Full record

SynthesisInternational journal of environmental research and public health2018

The Effectiveness and Cost-Effectiveness of Hepatitis C Screening for Migrants in the EU/EEA: A Systematic Review.

Christina Greenaway, Iuliia Makarenko, Claire Nour Abou Chakra, Balqis Alabdulkarim, Robin Christensen, Adam Palayew, Anh Tran, Lukas Staub, Manish Pareek, Joerg J Meerpohl and 5 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Hepatitis B and C Screening and Linkage to Care in Migrants From Endemic Countries in Barcelona Through a Community Action.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  6. Article
  7. Article
  8. Observational
  9. Prevalence of chronic conditions in Syrian refugees to Ottawa.Canadian family physician Medecin de famille canadien · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Health of Refugees and Migrants-Where Do We Stand and What Directions Should We Take?International journal of environmental research and public health · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 8 countries.

Christina GreenawayDivision of Infectious Diseases, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2 Canada. ca.greenaway@mcgill.ca.
Iuliia MakarenkoCentre for Clinical Epidemiology of the Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2. makarenko.j@gmail.com.
Claire Nour Abou ChakraDepartment of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1H 5NG, Canada. Claire.Nour.Abou.Chakra@USherbrooke.ca.
Balqis AlabdulkarimCentre for Clinical Epidemiology of the Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2. Balqis.alabdulkarim@mail.mcgill.ca.
Robin ChristensenMusculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Odense University Hospital, DK2000 Odense, Denmark. Robin.Christensen@regionh.dk.
Adam PalayewDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada. apalayew@gmail.com.
Anh TranNHMRC Clinical Trials Centre, The University of Sydney, Sydney 1450, Australia. anh.tran@ctc.usyd.edu.au.
Lukas StaubNHMRC Clinical Trials Centre, The University of Sydney, Sydney 1450, Australia. lukas.staub@ctc.usyd.edu.au.ORCID 0000-0002-2815-9107
Manish PareekDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 7RH, UK. manish.pareek@leicester.ac.uk.
Joerg J MeerpohlInstitute for Evidence in Medicine (for Cochrane Germany Foundation), Medical Center, University of Freiburg, 79110 Freiburg, Germany. meerpohl@ifem.uni-freiburg.de.ORCID 0000-0002-1333-5403
Teymur NooriEuropean Centre for Disease Prevention and Control, 169 73 Solna, Sweden. teymur.noori@ecdc.europa.eu.ORCID 0000-0002-8935-749X
Irene VeldhuijzenCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands. irene.veldhuijzen@rivm.nl.
Kevin PottieC.T. Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON K1N 5C8, Canada. kpottie@uottawa.ca.
Francesco CastelliDivision of Infectious Diseases, University of Brescia, 255123 Brescia, Italy. francesco.castelli@unibs.it.
Rachael L MortonNHMRC Clinical Trials Centre, The University of Sydney, Sydney 1450, Australia. Rachael.morton@ctc.usyd.edu.au.ORCID 0000-0001-7834-0572
Jewish General Hospital · CAThe University of Sydney · AUEuropean Centre for Disease Prevention and Control · SEFrederiksberg Hospital · DKMcGill University · CANational Institute for Public Health and the Environment · NLUniversité de Sherbrooke · CAUniversity of Brescia · ITUniversity of Freiburg · DEUniversity of Leicester · GBUniversity of Ottawa · CA

Funding

Department of Health PDF-2015-08-102
6 · The paper itself

Abstract

Chronic hepatitis C (HCV) is a public health priority in the European Union/European Economic Area (EU/EEA) and is a leading cause of chronic liver disease and liver cancer. Migrants account for a disproportionate number of HCV cases in the EU/EEA (mean 14% of cases and >50% of cases in some countries). We conducted two systematic reviews (SR) to estimate the effectiveness and cost-effectiveness of HCV screening for migrants living in the EU/EEA. We found that screening tests for HCV are highly sensitive and specific. Clinical trials report direct acting antiviral (DAA) therapies are well-tolerated in a wide range of populations and cure almost all cases (>95%) and lead to an 85% lower risk of developing hepatocellular carcinoma and an 80% lower risk of all-cause mortality. At 2015 costs, DAA based regimens were only moderately cost-effective and as a result less than 30% of people with HCV had been screened and less 5% of all HCV cases had been treated in the EU/EEA in 2015. Migrants face additional barriers in linkage to care and treatment due to several patient, practitioner, and health system barriers. Although decreasing HCV costs have made treatment more accessible in the EU/EEA, HCV elimination will only be possible in the region if health systems include and treat migrants for HCV.

Indexed as

Transients and MigrantsAntiviral AgentsCarcinoma, HepatocellularCost-Benefit AnalysisEthnicityEuropean UnionHepatitis CHumansLiver NeoplasmsMass ScreeningAntiviral AgentsEuropean Unionhepatitis Cmigrantsscreeningviral hepatitis elimination

Identifiers

PMID30223539
PMCPMC6164358
OpenAlexW2891693205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.