Proteasome-Rich PaCS as an Oncofetal UPS Structure Handling Cytosolic Polyubiquitinated Proteins. In Vivo Occurrence, in Vitro Induction, and Biological Role.

Enrico Solcia, Vittorio Necchi, Patrizia Sommi, Vittorio Ricci

Open access · goldAbstract readReview

In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 51% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

CagA Effector Protein inToxins · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Enrico SolciaDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. solciae@smatteo.pv.it.

Vittorio NecchiDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. vittorio.necchi@unipv.it.

Patrizia SommiDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. patrizia.sommi@unipv.it.

Vittorio RicciDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. vricci@unipv.it.

University of Pavia · ITPoliclinico San Matteo Fondazione · IT

Funding

Fondazione Cariplo (Milan, Italy) 2011-0485 and 2012-0529Italian Ministry of Education, University and Research Progetti di Ricerca di Interesse Nazionale, PRIN, and grant to the Department of Molecular Medicine of the University of Pavia under the initiative Dipartimenti di Eccellenza 2018-2022Italian Ministry of Health RF-2010-2310098

6 · The paper itself

Abstract

In this article, we outline and discuss available information on the cellular site and mechanism of proteasome interaction with cytosolic polyubiquitinated proteins and heat-shock molecules. The particulate cytoplasmic structure (PaCS) formed by barrel-like particles, closely reproducing in vivo the high-resolution structure of 26S proteasome as isolated in vitro, has been detected in a variety of fetal and neoplastic cells, from living tissue or cultured cell lines. Specific trophic factors and interleukins were found to induce PaCS during in vitro differentiation of dendritic, natural killer (NK), or megakaryoblastic cells, apparently through activation of the MAPK-ERK pathway. Direct interaction of CagA bacterial oncoprotein with proteasome was shown inside the PaCSs of a

Indexed as

AnimalsCell LineCytoplasmic StructuresCytosolExtracellular SpaceHeat-Shock ProteinsHumansInclusion BodiesInterleukinsIntracellular SpacePolyubiquitinProteasome Endopeptidase ComplexUbiquitinationHeat-Shock ProteinsInterleukinsPolyubiquitinProteasome Endopeptidase Complexaggresomesfetal cellsheat-shock proteinsmicrobial oncogenic proteinsneoplastic cellsPaCSpolyubiquitinated proteinsproteasomesequestosomestrophic factors/interleukins

Identifiers

PMID30223470

DOI10.3390/ijms19092767

PMCPMC6164709

OpenAlexW2891492276

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.